Christopher J . Destache, PharmD, FCCP, BCIDP

Professor

Pharmacy

C Destache

Contact

Medical Microbiology and Immunology (Doctorate)
Medical Microbiology and Immunology (Master of Science)
Pharmaceutical Sciences (Master of Science)
Graduate School
School of Pharmacy and Health Professions
Pharmacy
Pharmacy Faculty
Pharmacy Practice
Department of Medicine
Infectious Diseases Division
Faculty - Pharmacy, OT, PT
Infectious Diseases Fellowships
HLSB - Hixson Lied Science Building - 114

Christopher J . Destache, PharmD, FCCP, BCIDP

Professor

Pharmacy

Christopher J. Destache graduated from Creighton University in 1984 with his Doctor of Pharmacy degree.  After completing a one-year Family Medicine Research Fellowship, he was hired as the Director of the Clinical Pharmacokinetic Service at St. Joseph Hospital (now Creighton University Medical Center) and Assistant Professor of Pharmacy Practice, Creighton University (non-tenure).  He remained the Director of the CPS until 1993 when he moved to a tenure-track position at Creighton University School of Pharmacy and was promoted and tenured in 1995.  Dr. Destache practices and teaches in Infectious Diseases.  In 2006, he was promoted to Professor of Pharmacy Practice and Infectious Diseases at Creighton University Schools of Pharmacy and Medicine.  Dr. Destache precepts 4th year pharmacy students on the Infectious Diseases Consultation clerkship at Creighton University Medical Center – Bergan Mercy Hospital, is primarily involved with pre-exposure prophylaxis (PrEP) patients, teaches didactically in pharmacy and physician assistant programs and lectures to infectious diseases fellows.  Finally, Dr. Destache is involved with research projects dealing with clinical infectious diseases.

A more complete listing of scholarship, teaching, and research interests can be found on my Curriculum Vitae.

Curriculum Vitae

Research Focus

Pharmacology, nanomedicine, HIV

Department

Pharmacy Practice

Position

Professor

Presentations

  • Evusheld for Pre-exposure COVDI-19 2023 ID symposium 2023
  • HIV drugs. Family Medicine Grand Rounds 2022
  • Oral Antivirals for COVID-19 2022 ID Symposium 2022
  • A Little of This and Little of That: Finding COVID-19 Therapeutics. 2021 Infectious Diseases Symposium April 24, 2021 2021
  • Expanded role of the pharmacist during the COVID-19 pandemic Presented with Dr. Malesker for Rho Chi Society annual summer seminar Zoom meeting June 19, 2020. 2020
  • Augmented Renal Clearance: Peeing Antibiotics Fast. Midwest College of Clinical Pharmacy CE meeting. Omaha, NE. January 15, 2020 2020
  • Available therapy for resistant Gram-negative bacilli: A changing picture. Presented at the 2019 Infectious Diseases Spring Symposium. CHI Health Creighton University Medical Center-Bergan Mercy April 27, 2019. 2019
  • HIV PrEP. Presented at Multi-Cultural Health Science Student Association (MCHSS). Jan 15, 2019. 2019
  • Antiretroviral nanoparticles: From PrEP to treatment to functional cure. Nebraska Center for Virology May 4, 2018. 2018
  • HIV PrEP: Who, What, When, Why presented at the 2018 Infectious Diseases Symposium CHI Health Bergan Mercy Medical Center April 28. 2018. 2018
  • Shipley S, Cavalieri S, Vivekanandan R, Destache CJ. Evaluation of the management of ESBL-producing Enterobacteriaceae infections: CHI Health Omaha. (Abstract 62548) IDWeek San Diego, CA. Oct 7-10, 2017. Presented as a poster. 2017
  • Mandal S, Kang G, Prathipati P, Zhou Y, Yuan Z, Fan W, Li Q, Destache C. A comparison study of tenofovir alafenamide (TAF) plus emtricitabine (FTC) in solution and as nanoparticles (NPs) for pre-exposure prophylaxis (PrEP) in humanized BLT (hu-BLT) mice (Abstract WEPEA0194). 9th IAS Conference on HIV Science. Paris, Fr July 23-26, 2017. Presented as a poster. 2017
  • Antimicrobial stewardship program. St. Francis Regional Medical Center. 2017
  • Antimicrobial stewardship program. St. Francis Regional Medical Center. May 14, 2017 2017
  • Antiretroviral nanoparticles for PrEP. NE Center for Virology Inter-Campus Annual Retreat 2017
  • Antiretroviral nanoparticles for PrEP. NE Center for Virology Inter-Campus Annual Retreat March 20, 2017. 2017
  • Ased S, Vivekanandan R, Anthone J, Rayes H, Dhami J, Cabri A, Davids M, Amosson T, Macaraeg J, Fordjour A, Wilson J, Cavalieri S, Destache C. A Comparison of Staphylococcus aureus Bacteremia (SAB) Diagnosis and Management: Differences Between Academic and Community Hospital Settings. (#1030) IDWeek. New Orleans, LA Oct 26-30, 2016. Presented as a poster. 2016
  • "Antiretroviral Nanoparticles for HIV-1 Treatment and Prevention" Biomedical Sciences Department, Creighton University 2016
  • "Exploring antiretroviral nanomedicines for treatment and prevention of HIV infection". Invited presentation Department of Pharmacy Sciences, School of Pharmacy, Creighton University. 2016
  • Exploring antiretroviral nanomedicines for treatment and prevention of HIV infection. Invited presentation Tulane National Primate Research Center. 2016
  • Exploring antiretroviral nanomedicines for treatment and prevention of HIV infection. Invited presentation Tulane National Primate Research Center. September 16, 2016. 2016
  • Natural polyphenols: Use against viral STI. Northwest Regional Chemical Society, Anchorage, AK 2016
  • Natural polyphenols: Use against viral STI. Northwest Regional Chemical Society, Anchorage, AK June 28, 2016. 2016
  • Mandal S, Kang G, Yuan Z, Lu W, Prathipati PK, Li Q, Destache CJ. Combination antiretroviral (cARV) drug loaded nanoparticles (NPs) are efficacious in humanized (HuBLT) mice. (Abstract #SU-408) 2016 ASM-Microbe Conference. Boston, MA Jun 16-20, 2016. Presented as a poster. 2016
  • New Antimicrobials. Creighton University Infectious Diseases Symposium. Omaha, NE 2016
  • New Antimicrobials. Creighton University Infectious Diseases Symposium. Omaha, NE April 23, 2016. 2016
  • Destache CJ, Mandal S, Prathipati PK. TDF/EVG nanoparticle formulation: plasma pharmacokinetics in humanized mice. (Abstract #16-1812) Conference on Retroviruses and Opportunistic Infections. Boston, MA Feb 22-25, 2016. Presented as a poster 2016
  • Rapid Viral Respiratory Pathogen Identification. MEDS symposium. Omaha, NE 2014
  • Antiretroviral nanoparticles for HIV infection. Presented at the 2014 ACCP Annual Meeting, Austin, TX October 14, 2014. 2014
  • HIV Treatment Up-date and Treatment of Hepatitis C. Alaska Pharmacists Association annual meeting. 2014
  • Topical tenofovir nanoparticle application prevents HIV-1 vaginal transmission in humanized-BLT mice. Nebraska Center for Virology Annual retreat, Nebraska City, NE 2014
  • Evaluation of nanomedicine for HIV treatment and prevention. Distinguished Lecture Series. Texas Tech Center of Excellence in Infectious Diseases, Texas Tech University Health Sciences Center, El Paso, TX 2014
  • Cerebrospinal fluid penetration and pharmacokinetics of anti-infective agents. Presented at the 2013 AAPS Annual Meeting and Exposition, San Antonio, TX 2013
  • Development of a nanoparticle-based thermosensitive vaginal gel for HIV prevention. 47th American Chemical Society Regional Meeting. Omaha, NE 2012
  • In vivo levels of ritonavir, lopinavir, efavirenz over time after intraperitoneal injection of antiretroviral PLGA nanoparticle. Part of the Great 8 abstracts presented at the 30th American College of Clinical Pharmacy meeting. Anaheim, CA 2009
  • Assessing Current Threats: Natural and Man-Made. 38th Midyear Clinical Meeting of the American Society for Health-System Pharmacists. New Orleans, LA. 2003
  • Statistics in Review. 10th Annual Pediatric Pharmacy Advisory Group Meeting. St. Louis, MO 2001
  • Statistics in Review. 10th Annual Pediatric Pharmacy Advisory Group Meeting. St. Louis, MO 2001
  • Optimizing Economic Outcomes in Respiratory Tract Infections. Satellite Symposium to the American College of Clinical Pharmacy annual meeting, Los Angeles, CA 2000
  • Nitric Oxide Concentrations in S. pneumoniae Meningitis: Correlation to Cytopathology. Presented at the Society of Infectious Diseases Pharmacists Annual Meeting Toronto, Canada 1997
  • Economic Evaluation of Clinical Pharmacy Services. Presented at the 1996 American Society of Health System Pharmacists Annual Meeting, San Diego, CA. 1996
  • Economic Evaluation of Clinical Pharmacy Services. Presented at the 1995 American Society of Health System Pharmacists Midyear Clinical Meeting, Las Vegas, NV. 1995
  • Moderator for Specialty Practice Group in Clinical Pharmacokinetics at the 1993 Midyear Clinical Meeting of the American Society of Hospital Pharmacists, Atlanta, GA. Topic: "Reimbursement Issues for Clinical Pharmacokinetics." 1993
  • Does Accepting Pharmacokinetic Recommendations Impact Hospitalization? A Cost-Benefit Analysis. Platform presentation at the American Society of Hospital Pharmacists 24th Midyear Clinical Meeting, Atlanta, GA. 1989
  • "Clinical Pharmacokinetics" at the Career Consultation Section of the 24th American Society of Hospital Pharmacists Midyear Clinical Meeting, Atlanta, GA. 1989
  • Impact of a Clinical Pharmacokinetic Service on Patients Treated with Aminoglycosides: A Cost-Benefit Analysis. Platform presentation at the 10th Annual American College of Clinical Pharmacy Meeting, Kansas City, MO. 1989
  • Inpatient Temperature Monitoring during the Transition of IV to Oral Antibiotics in the Treatment of Pyelonephritis: Is it necessary? Platform presentation at North American Primary Care Research Group Meeting, Seattle, WA. 1985

Awards

  • Department of Medicine Best Fellow Research Award
    2019 Creighton University School of Medicine, Department of Medicine Best Fellow Research Award
    Creighton University School of Medicine
  • Scholarly Achievement Award
    Creighton University School of Pharmacy & Allied Health Professions
  • Scholarly Achievement Award
    Creighton University School of Pharmacy & Allied Health Professions