Andrew E . Ekpenyong, MS, PhD
Associate Professor
Physics
Contact
College of Arts and Sciences
Graduate School
Medical Physics (Master of Science)
Physics (Master of Science)
Physics
African Studies
Hixson Lied Science Building G71
Andrew E . Ekpenyong, MS, PhD
Associate Professor
Physics
Teaching Interests
- Medical Physics (didactic and research)
Research Focus
Almost all the vital signs are biophysical properties: blood pressure, pulse rate, body temperature, etc. With collaborators from the Departments of Chemistry, Physics and Mathematics, the School of Medicine, Creighton University, as well as international collaborators in the UK and Germany, I develop and use novel biophysical tools to discover new biomarkers that provide diagnostic information and new therapeutic options. I address the physician’s wish list in order to improve disease diagnosis, patient monitoring, drug development and testing, etc. While these efforts seek to improve biomedicine using principles and tools of physics, I also aim at advancing the physics of complex systems such as living matter. In particular, I seek to understand how biological cells function as mechanical units, with material properties.Department
Physics
Position
Associate Professor
Books
- Ekpenyong Andrew E., Mathematical physics for nuclear experiments 2022
Book, Chapter/Section
- Mathematical Physics for Nuclear Experiments
Ekpenyong Andrew E, Probability and Statistics for Nuclear Experimental Data [Book Chapter] 2022 - Mathematical Physics for Nuclear Experiments
Ekpenyong Andrew E, Radioactivity and Decay Law [Book Chapter] 2022 - Mathematical Physics for Nuclear Experiments
Ekpenyong Andrew E, Energy Loss of Electrons and Positrons through Matter [Book Chapter] 2022 - Mathematical Physics for Nuclear Experiments
Ekpenyong Andrew E, Energy Loss of Heavy Charged Particles through Matter [Book Chapter] 2022 - Mathematical Physics for Nuclear Experiments
Ekpenyong Andrew E, Interactions of Photons in Matter [Book Chapter] 2022 - Methods in Molecular Biology
Djam Kimal Honour, Lee Bong Han, Suresh Sindhuja, Ekpenyong Andrew Edet, Quantum Dots for Assessment of Reactive Oxygen Species Accumulation During Chemotherapy and Radiotherapy [Book Chapter] 2020 - Methods in Cell Biology
Schurmann M., Scholze J., Muller P., Chan C. J., Ekpenyong Andrew E., Chalut K. J., Guck J., Refractive index measurements of single, spherical cells using digital holographic microscopy [Book Chapter] 2015
General
- Lee Bong H., Ekpenyong Andrew, Suresh Sindhuja, Fluorescence intensity modulation of CdSe/ZnS quantum dots assesses reactive oxygen species during chemotherapy and radiotherapy for cancer cells 2019
- Ekpenyong Andrew E., Man Si Ming, Achouri Sarra, Bryant Clare E., Guck Jochen, Chalut Kevin J., Bacterial infection of macrophages induces decrease in refractive index 2013
Publications
- Micromachines (Basel)
Abraham Ashley, Virdi Sukhman, Herrero Nick, Bryant Israel, Nwakama Chisom, McCuddin Mackenzie, McKinley Spencer, Taylor Adam, Jacob Megha, Khaparde Gargee, Jordan Destiny, Peeples Conner, Ekpenyong Andrew, Microfluidic Microcirculation Mimetic for Exploring Biophysical Mechanisms of Chemotherapy-Induced Metastasis
14:9, p. 1653 2023 - Life (Basel, Switzerland)
McKinley Spencer, Taylor Adam, Peeples Conner, Jacob Megha, Khaparde Gargee, Walter Yohan, Ekpenyong Andrew, Simulated Microgravity-Induced Changes to Drug Response in Cancer Cells Quantified Using Fluorescence Morphometry
13:8, p. 1683 2023 - Biomedicines
Walter Yohan, Salas Olivia, Jordan Destiny, Ekpenyong Andrew, Hubbard Anne, Benoit Allie, Jank Erika, Development of In Vitro Assays for Advancing Radioimmunotherapy against Brain Tumors
10:8 2022 - Applied Sciences (Switzerland)
Asuquo Marcus Inyama, Gbotosho Oluwabukola, Otu Akaninyene, Toepfner Nicole, Ameh Soter, Bhayankaram Sruti Prathivadhi, Zetocha Noah, Nwakama Chisom, Egbe William, Guck Jochen, Effa Emmanuel, Ekpenyong Andrew, Microfluidic Microcirculation Mimetic as a Tool for the Study of Rheological Characteristics of Red Blood Cells in Patients with Sickle Cell Anemia
12:9 2022 - Biophysical journal
Virdi Sukhman, Herrero Nicholas, Bryant Israel, Jordan Destiny, Abraham Ashley, Khaparde Gargee, Jacob Megha, Nwakama Chisom, Ekpenyong Andrew E., The role of cell mechanics in chemotherapy-induced metastasis
121:3, p. 266a - 266a 2022 - Biochemistry and Biophysics Reports
Merrick Michael, Mimlitz Michael J., Weeder Catherine, Akhter Haris, Bray Allie, Walther Andrew, Nwakama Chisom, Bamesberger Joe, Djam Honour, Abid Kaamil, Ekpenyong Andrew, In vitro radiotherapy and chemotherapy alter migration of brain cancer cells before cell death
27 2021 - Pharmaceutical Research
Palliyage Gayathri Heenatigala, Hussein Noor, Mimlitz Michael, Weeder Catherine, Alnasser Marya Hassan A., Singh Somnath, Ekpenyong Andrew, Tiwari Amit K., Chauhan Harsh, Novel Curcumin-Resveratrol Solid Nanoparticles Synergistically Inhibit Proliferation of Melanoma Cells
38:5, p. 851 - 871 2021 - Biophysical journal
Abraham Ashley, McCuddin Mackenzie, Nwakama Chisom, Jacob Megha, Khaparde Gargee, Baumel Scott, Mckinley Spencer, Lewison Jack, Virdi Sukhman, Jordan Destiny, Kramer Harry, Ekpenyong Andrew E., Which Chemotherapy Drugs Alter Cell Mechanical Properties with Impact on Metastasis?
120:3, p. 66a - 66a 2021 - Pan African Medical Journal
Otu Akaninyene, Effa Emmanuel, Umoh Victor, Maxwell Nicholas, Ekpenyong Andrew, Private sector initiatives to tackle the burden of covid-19
38 2021 - Life
Prasanth Devika, Suresh Sindhuja, Prathivadhi-Bhayankaram Sruti, Mimlitz Michael, Zetocha Noah, Lee Bong, Ekpenyong Andrew, Microgravity modulates effects of chemotherapeutic drugs on cancer cell migration
10:9, p. 1 - 11 2020 - Nature Methods
Wu Pei Hsun, Aroush Dikla Raz Ben, Asnacios Atef, Poh Yeh Chuin, Ros Robert, Sander Mathias, Sokolov Igor, Staunton Jack R., Wang Ning, Whyte Graeme, Wirtz Denis, Chen Wei Chiang, Dokukin Maxim E., Doss Bryant L., Durand-Smet Pauline, Ekpenyong Andrew, Guck Jochen, Guz Nataliia V., Janmey Paul A., Lee Jerry S.H., Moore Nicole M., Ott Albrecht, A comparison of methods to assess cell mechanical properties
15:7, p. 491 - 498 2018 - Biophysical journal
Ekpenyong Andrew E., Abid Kaamil, Han Lee Bong, Mimlitz Michael, Zetocha Noah, Effects of Ionizing Radiation on the Mechanosensitivity of Single Cells
114:3, p. 514 - 514a 2018 - Open Access Macedonian Journal of Medical Sciences
Ikpeme Anthonia, Effa Emmanuel, Kosoko-Lasaki Omofolasade, Ekpenyong Andrew, Ani Nchiewe, Ago Boniface, The value of mobile ultrasound services in rural communities in South-South Nigeria
5:7, p. 1011 - 1015 2017 - Science Advances
Ekpenyong Andrew E., Herbig Maik, Summers Charlotte, Guck Jochen, Chilvers Edwin R., Li Wenhong, Cojoc Gheorghe, Fiddler Christine, Toepfner Nicole, Mechanical Deformation Induces Depolarization of Neutrophils
3:6, p. e1602536 - e1602536 2017 - Biophysical journal
Prasanth Devika, Suresh Sindhuja, Mimlitz Michael, Zetocha Noah, Ekpenyong Andrew E., Microgravity Modulates Drug-Induced Enhancement of Cancer Cell Migration
112:3, p. 311a - 311a 2017 - Biophysical Journal
Prathivadhi-Bhayankaram Sruti V., Nichols Michael, Guck Jochen, Ekpenyong Andrew E., Ning Jianhao, Mimlitz Michael, Gross Erin, Taylor Carolyn, Chemotherapy impedes in vitro microcirculation and promotes migration of leukemic cells with impact on metastasis
112:3, p. 124a - 124a 2017 - Biophysical journal
Prathivadhi-Bhayankaram Sruti V., Taylor Carolyn E., Ning Jianhao, Nichols Michael, Ekpenyong Andrew E., Cell Mechanical Properties and Cancer Metastasis: Effects of Cancer Drugs and Radiotherapy
110:3, p. 621a - 621a 2016 - Biochemical and Biophysical Research Communications
Prathivadhi-Bhayankaram Sruti, Ning Jianhao, Mimlitz Michael, Taylor Carolyn, Gross Erin M., Nichols Michael G., Guck Jochen, Ekpenyong Andrew E., Chemotherapy Impedes in Vitro Microcirculation and Promotes Migration of Leukemic Cells with Impact on Metastasis
479:4, p. 841 - 846 2016 - Biochimica et Biophysica Acta
Ekpenyong Andrew E., Toepfner N., Chilvers E. R., Guck J., Mechanotransduction in neutrophil activation and deactivation, p. (12 pages) 2015 - Biophysical Journal
Chan Chii J., Ekpenyong Andrew E., Golfier Stefan, Li Wenhong, Chalut Kevin J., Otto Oliver, Elgeti Jens, Guck Jochen, Lautenschläger Franziska, Myosin II activity softens cells in suspension
108:8, p. 1856 - 1869 2015 - Nature Methods
Otto O., Mietke A., Golfier S., Herold C., Klaue D., Rosendahl P., Girardo S., Pagliara S., Ekpenyong Andrew E., Jacobi A., Wobus M., Topfner N., Keyser U. F., . . . Guck, J., Real-time deformability cytometry: on-the-fly cell mechanical phenotyping
12:3, p. 199 - 202 2015 - Proceedings of the National Academy of Sciences of the United States of America
Man Si Ming, Ng Gilbert, Wright John A., Cicuta Pietro, Guck Jochen R., Bryant Clare E., Ekpenyong Andrew, Tourlomousis Panagiotis, Achouri Sarra, Cammarota Eugenia, Hughes Katherine, Rizzo Alessandro, Actin polymerization as a key innate immune effector mechanism to control Salmonella infection
111:49, p. 17588 - 17593 2014 - Interface Focus
Holmes David, Whyte Graeme, Bailey Joe, Vergara-Irigaray Nuria, Ekpenyong Andrew, Guck Jochen, Duke Tom, Separation of blood cells with differing deformability using deterministic lateral displacement
4:6 2014 - Biophysical journal
Ekpenyong Andrew, Guck Jochen, The Evolution of Mechanical Properties of Differentiating Stem Cells is Fate- and Function-Dependent
106:2, p. 42a - 42a 2014 - Acta Mechanica
Boyde Lars, Guck Jochen, Ekpenyong Andrew, Whyte Graeme, Elastic theory for the deformation of a solid or layered spheroid under axisymmetric loading
224:4, p. 819 - 839 2013 - Biophysical Journal
Chalut Kevin J., Höpfler Markus, Lautenschläger Franziska, Boyde Lars, Chan Chii Jou, Ekpenyong Andrew, Martinez-Arias Alfonso, Guck Jochen, Chromatin decondensation and nuclear softening accompany Nanog downregulation in embryonic stem cells
103:10, p. 2060 - 2070 2012 - Applied Optics
Boyde Lars, Ekpenyong Andrew, Whyte Graeme, Guck Jochen, Comparison of stresses on homogeneous spheroids in the optical stretcher computed with geometrical optics and generalized lorenz–mie theory
51:33, p. 7934 - 7944 2012 - PloS one
Ekpenyong Andrew E., Whyte Graeme, Chalut Kevin, Pagliara Stefano, Lautenschläger Franziska, Fiddler Christine, Paschke Stephan, Keyser Ulrich F., Chilvers Edwin R., Guck Jochen, Viscoelastic Properties of Differentiating Blood Cells Are Fate- and Function-Dependent
7:9 2012 - Integrative biology : quantitative biosciences from nano to macro
Chalut Kevin J., Ekpenyong Andrew E., Clegg Warren L., Melhuish Isabel C., Guck Jochen, Quantifying cellular differentiation by physical phenotype using digital holographic microscopy.
4:3, p. 280 - 284 2012 - Journal of Biophotonics
Jacobs Kenneth M., Yang Li V., Ding Junhua, Ekpenyong Andrew E., Castellone Reid, Lu Jun Q., Hu Xin Hua, Diffraction imaging of spheres and melanoma cells with a microscope objective
2:8-9, p. 521 - 527 2009 - Applied Optics
Ekpenyong Andrew E., Posey Carolyn L., Chaput Joy L., Burkart Anya K., Marquardt Meg M., Smith Timothy J., Nichols Michael G., Determination of cell elasticity through hybrid ray optics and continuum mechanics modeling of cell deformation in the optical stretcher
48:32, p. 6344 - 6354 2009
Grants
CytoSMART Omni Instrument/Sponsor: State of Nebraska - LB692
Physics of Cancer: Role of Cell Mechanics in Chemotherapy-Induced Metastasis/Sponsor: CURAS Magis Investigatio Research Award/MIRA
Science in Space to Cure Disease on Earth: Using Simulated Microgravity for Cancer Tissue Engineering/Sponsor: CURAS Magis Investigatio Research Award/MIRA
Using Simulated Microgravity for Cancer Tissue Engineering/Sponsor: University of Nebraska at Omaha/UNO
Microgravity for 3D Microphysiological Systems in Cancer Therapeutics/Sponsor: University of Nebraska at Omaha/UNO