Clifford Gee, PhD

Department

Chemistry and Biochemistry

Position

Assistant Professor

Books

• , Applications of Fluorine Magnetic Resonance for Small-Molecule Screening, Ligand Development, and Oxygen Sensing 2017

Publications

• mBio
  Miao Yi, etal Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways 2025
• Nature communications
  Scott Daniel C, etal Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2
  15:1, p. 8829 - 19 2024
• Molecular Cell
  Scott Daniel C., etal E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity
  83:5 2023
• ACS Medicinal Chemistry Letters
  Buchholz Caroline R., etal Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors
  14:10 2023
• Tuberculosis
  Fernando Dinesh M., etal Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket
  132 2022
• Journal of Medicinal Chemistry
  Cui Huarui, etal A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes
  65:3 2022
• Tuberculosis
  Fernando Dinesh M., etal Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringe
  132 2022
• Journal of Chemical Education
  Bur Scott K., etal Fragment-Based Ligand Discovery Using Protein-Observed 19F NMR: A Second Semester Organic Chemistry CURE Project
  98:6 2021
• Nature Communications
  Yang Seung Wook, etal Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
  11:1 2020
• ACS Infectious Diseases
  Wallace Miranda J., etal Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria
  6:3 2020
• ACS Infectious Diseases
  Grzegorzewicz Anna E., etal Mechanisms of Resistance Associated with the Inhibition of the Dehydration Step of Type II Fatty Acid Synthase in Mycobacterium tuberculosis
  6:2 2020
• ChemBioChem
  Gee Clifford T., etal Dual Labeling of the CBP/p300 KIX Domain for 19F NMR Leads to Identification of a New Small-Molecule Binding Site
  19:9 2018
• Journal of Medicinal Chemistry
  Ayoub Alex M., etal BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen
  60:12 2017
• ACS Nano
  Lee Amani L., etal Oxygen Sensing with Perfluorocarbon-Loaded Ultraporous Mesostructured Silica Nanoparticles
  11:6 2017
• Journal of Chemical Education
  Gee Clifford T., etal Quantifying Protein Concentrations Using Smartphone Colorimetry: A New Method for an Established Test
  94:7 2017
• Nature Protocols
  Gee Clifford T., etal Protein-observed 19F-NMR for fragment screening, affinity quantification and druggability assessment
  11:8 2016
• RSC Advances
  Hawk Laura M. L., etal Paramagnetic relaxation enhancement for protein-observed 19F NMR as an enabling approach for efficient fragment screening
  6:98 2016
• Angewandte Chemie - International Edition
  Gee Clifford T., etal Fragment screening and druggability assessment for the CBP/p300 KIX domain through protein-observed 19F NMR spectroscopy
  54:12 2015

Grants

• INBRE: Protein Tetris: Profiling Substrates of the Bacterial Peptide Transporters SaOpp3A and SaDtpT/Sponsor: University of Nebraska Medical Center/UNMC

• INBRE: Protein Tetris: Profiling the Substrates of Bacterial Transporters/Sponsor: University of Nebraska Medical Center/UNMC

Awards

• 2023 IGGY Award
  Office of Student Success