Claudia Gragnoli, MD, PhD

Department

Medicine

Position

Professor

Articles

• Gragnoli Claudia, Erratum 2005

Publications

• Physics of life reviews
  Che Jincan, etal High-order interaction modeling of tumor-microenvironment crosstalk for tumor growth 2025
• European archives of psychiatry and clinical neuroscience
  Amin Mutaz, etal Secondary analysis of GenRED data (Genetics of Recurrent Early-Onset major Depression) using MERLIN 2025
• Physics reports
  Feng Li, etal Network modeling and topology of aging
  1101, p. 1 - 65 2025
• Clinical nutrition open science
  Gragnoli Claudia, etal Cinnamon treatment shows promise for glycemic control but may cause adverse effects in some people 2025
• Journal of ovarian research
  Wu Rongling, etal The melanocortin receptor genes are linked to and associated with the risk of polycystic ovary syndrome in Italian families
  17:1, p. 242 - 5 2024
• Aspects of molecular medicine
  Amin Mutaz, etal Genome-wide linkage and association of novel genes and pathways with type 2 diabetes in Italian families
  4 2024
• Drug discovery today
  Che Jincan, etal IdopNetwork as a genomic predictor of drug response, p. 104252 2024
• Journal of ovarian research
  Goparaju Pruthvi, etal Implication of vasopressin receptor genes (AVPR1A and AVPR1B) in the susceptibility to polycystic ovary syndrome
  17:1, p. 214 2024
• Proceedings of the National Academy of Sciences - PNAS
  Feng Li, etal Hypernetwork modeling and topology of high-order interactions for complex systems
  121:40, p. e2412220121 2024
• Aspects of molecular medicine
  Wu Rongling, etal Linkage and association of rs3110045 and rs28499085 variants in the thyrotropin-releasing hormone receptor (TRHR) gene with the risk of familial type 2 diabetes
  3 2024
• Journal of ovarian research
  Postolache Teodor T, etal The melatonin receptor genes are linked and associated with the risk of polycystic ovary syndrome
  17:1, p. 17 - 17 2024
• Journal of ovarian research
  Syed Shumail, etal The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families
  17:1, p. 13 - 13 2024
• European archives of psychiatry and clinical neuroscience
  Del Bosque-Plata Laura, etal LD block disorder-specific pleiotropic roles of novel CRHR1 in type 2 diabetes and depression disorder comorbidity 2023
• Journal of ovarian research
  Amin Mutaz, etal The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome
  16:1, p. 222 - 222 2023
• Proceedings of the National Academy of Sciences - PNAS
  Wu Shuang, etal The metabolomic physics of complex diseases
  120:42, p. e2308496120 - e2308496120 2023
• European review for medical and pharmacological sciences
  Amin M, etal Author Correction: Linkage and association of novel DRD2 variants to the comorbidity of type 2 diabetes and depression
  27:18, p. 8322 - 8322 2023
• Drug discovery today
  Wang Yu, etal A pleiotropic–epistatic entangelement model of drug response, p. 103790 2023
• Journal of ovarian research
  Amin Mutaz, etal Linkage and association of variants in the dopamine receptor 2 gene (DRD2) with polycystic ovary syndrome
  16:1, p. 158 - 158 2023
• Genes & diseases
  Amin Mutaz, etal The role of melatonin receptor 1B gene (MTNR1B) in the susceptibility to depression and type 2 diabetes comorbidity 2023
• Drug discovery today
  Feng Li, etal A personalized pharmaco-epistatic network model of precision medicine
  28:7, p. 103608 - 103608 2023
• European review for medical and pharmacological sciences
  Amin M, etal Melatonin receptor 1A (MTNR1A) gene linkage and association to type 2 diabetes in Italian families
  27:10, p. 4688 2023
• International journal of molecular sciences
  Amin Mutaz, etal Novel Risk Variants in the Oxytocin Receptor Gene (OXTR) Possibly Linked to and Associated with Familial Type 2 Diabetes
  24:7, p. 6282 2023
• European review for medical and pharmacological sciences
  Amin M., etal Oxytocin receptor (OXTR) is a risk gene for polycystic ovarian syndrome
  27:6, p. 2634 - 2638 2023
• European review for medical and pharmacological sciences
  Amin M., etal The mineralocorticoid receptor gene (NR3C2) is linked to and associated with polycystic ovarian in Italian families
  27:3, p. 942 - 948 2023
• Aspects of Molecular Medicine
  Amin Mutaz, etal Novel linkage and association of the mineralocorticoid receptor gene (NR3C2) with familial type 2 diabetes and depression and their comorbidity
  1 2023
• Journal of the Endocrine Society
  Amin Mutaz, etal ODP258 CRHR1 gene shows extensive linkage to major depression and type 2 diabetes in Italian families
  6:Supplement_1, p. A339 - A340 2022
• International journal of molecular sciences
  Amin Mutaz, etal Familial Linkage and Association of the NR3C1 Gene with Type 2 Diabetes and Depression Comorbidity
  23:19, p. 11951 2022
• International journal of molecular sciences
  Amin Mutaz, etal Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression
  23:17 2022
• International journal of molecular sciences
  Amin Mutaz, etal Implication of Melanocortin Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression
  23:15 2022
• Journal of Cellular Physiology
  del Bosque-Plata Laura, etal The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes
  237:1, p. 301 - 312 2022
• Diabetes
  Del Bosque-Plata Laura, etal The Role of TCF7L2 in Type 2 Diabetes
  70:6, p. 1220 - 1228 2021
• Gut Microbes
  Jiang Libo, etal A behavioral model for mapping the genetic architecture of gut-microbiota networks
  13:1 2021
• Cancers
  Sun Lidan, etal Computational identification of gene networks as a biomarker of neuroblastoma risk
  12:8, p. 1 - 17 2020
• Journal of Psychiatric Research
  Akram Faisal, etal Seasonal affective disorder and seasonal changes in weight and sleep duration are inversely associated with plasma adiponectin levels
  122, p. 97 - 104 2020
• Computational and Structural Biotechnology Journal
  Sang Mengmeng, etal A rewiring model of intratumoral interaction networks
  18, p. 45 - 51 2020
• iScience
  Jiang Libo, etal A Drive to Driven Model of Mapping Intraspecific Interaction Networks
  22, p. 109 - 122 2019
• Biological psychiatry (1969)
  Wadhawan Abhishek, etal S144. Obesity is Associated With Anhedonia Only in the Younger Amish Women
  85:10, p. S352 - S352 2019
• American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
  Postolache Teodor T., etal Co-shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic syndrome
  180:3, p. 186 - 203 2019
• Drug Discovery Today
  Wang Qian, etal A unified mapping framework of multifaceted pharmacodynamic responses to hypertension interventions
  24:3, p. 883 - 889 2019
• Drug Discovery Today
  Wei Kun, etal Mapping genes for drug chronotherapy
  23:11, p. 1883 - 1888 2018
• Gragnoli Claudia, etal Breastfeeding and future maternal health- no causal evidence 2018
• Pteridines
  Ahmad Zaki, etal Sleep onset insomnia, daytime sleepiness and sleep duration in relationship to Toxoplasma gondii IgG seropositivity and serointensity
  28:3-4, p. 195 - 204 2017
• Pteridines
  Mohyuddin Hira, etal Seasonality of blood neopterin levels in the Old Order Amish
  28:3-4, p. 163 - 176 2017
• Frontiers in Public Health
  Mathai Ashwin Jacob, etal Blood Levels of Monoamine Precursors and Smoking in Patients with Schizophrenia
  4 2016
• Trends in Genetics
  Zhu Xuli, etal Integrating Evolutionary Game Theory into Mechanistic Genotype-Phenotype Mapping
  32:5, p. 256 - 268 2016
• Translational Psychiatry
  Gragnoli C., etal Dopamine–prolactin pathway potentially contributes to the schizophrenia and type 2 diabetes comorbidity
  6:4 2016
• Scientific Reports
  Hao Han, etal T2D and Depression Risk Gene Proteasome Modulator 9 is Linked to Insomnia
  5 2015
• Journal of Cellular Physiology
  Gragnoli Claudia, Proteasome modulator 9 gene SNPs, responsible for anti-depressant response, are in linkage with generalized anxiety disorder
  229:9, p. 1157 - 1159 2014
• Application of Clinical Genetics
  Gragnoli Claudia, Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, and metabolic syndrome
  7, p. 43 - 53 2014
• Cardiovascular Diabetology
  Gragnoli Claudia, Overweight condition and waist circumference and a candidate gene within the 12q24 locus
  12:1 2013
• Current Medicinal Chemistry
  Gragnoli C., Proteasome modulator 9 and depression in type 2 diabetes
  19:30, p. 5178 - 5180 2012
• Journal of Cellular Physiology
  Oberweis Brandon, etal Potential role of prolactin in antipsychotic-mediated association of schizophrenia and type 2 diabetes
  227:8, p. 3001 - 3006 2012
• Journal of Cellular Physiology
  Gragnoli Claudia, Proteasome modulator 9 is linked to microvascular pathology of T2D
  227:8, p. 3116 - 3118 2012
• Journal of Cellular Physiology
  Gragnoli Claudia, Depression and type 2 diabetes
  227:6, p. 2318 - 2322 2012
• Diabetes Research and Clinical Practice
  Gragnoli Claudia, Proteasome modulator 9 and carpal tunnel syndrome
  94:2, p. e47 - e49 2011
• Ophthalmic Genetics
  Gragnoli Claudia, Proteasome modulator 9 gene is linked to diabetic and non-diabetic retinopathy in T2D
  32:4, p. 228 - 230 2011
• Journal of Diabetes and its Complications
  Gragnoli Claudia, PSMD9 is linked to type 2 diabetes neuropathy
  25:5, p. 329 - 331 2011
• Cardiovascular Diabetology
  Gragnoli Claudia, Proteasome Modulator 9 SNPs are linked to hypertension in type 2 diabetes families
  10 2011
• Diabetes Research and Clinical Practice
  Gragnoli Claudia, T2D-nephropathy linkage within 12q24 locus
  92:3, p. e73 - e75 2011
• Cardiovascular Diabetology
  Gragnoli Claudia, Hypercholesterolemia and a candidate gene within the 12q24 locus
  10 2011
• Cardiovascular Diabetology
  Gragnoli Claudia, Proteasome modulator 9 and macrovascular pathology of T2D
  10 2011
• Journal of diabetes & metabolism
  Gragnoli Claudia, Insomnia linked to a T2D Gene
  1:S1 2011
• Journal of Cellular Physiology
  Gragnoli Claudia, PSMD9 is linked to MODY3
  223:1, p. 1 - 5 2010
• Journal of Cellular Physiology
  Gragnoli Claudia, PSMD9 gene in the NIDDM2 locus is linked to type 2 diabetes in Italians
  222:2, p. 265 - 267 2010
• Journal of Cellular Physiology
  Meenakshisundaram Ramachandran, etal CDK4 IVS4-nt40G→A and T2D-associated obesity in Italians rapid communication
  221:2, p. 273 - 275 2009
• Diabetes Research and Clinical Practice
  Meenakshisundaram Ramachandran, etal CDK4 IVS4-nt40G → A SNP and type 2 diabetes in Italians
  86:2, p. e28 - e30 2009
• Obesity Surgery
  Spanakis Elias, etal Successful medical management of status post-roux-en-y-gastric-bypass hyperinsulinemic hypoglycemia
  19:9, p. 1333 - 1334 2009
• Obesity Surgery
  Spanakis Elias, etal Bariatric surgery, safety and type 2 diabetes
  19:3, p. 363 - 368 2009
• Journal of Experimental and Clinical Cancer Research
  Meenakshisundaram Ramachandran, etal CDK4 IVS4-nt40 AA genotype and obesity-associated tumors/cancer in Italians - A case-control study
  28:1 2009
• Journal of Experimental and Clinical Cancer Research
  Meenakshisundaram Ramachandran, etal CHOP 5'UTR-c.279TC and +nt30CT variants are not associated with overweight condition or with tumors/cancer in Italians-a case-control study
  28:1 2009
• Journal of Cellular Physiology
  Spanakis Elias, etal AVPR2 variants and mutations in nephrogenic diabetes insipidus
  217:3, p. 605 - 617 2008
• Journal of Cellular Physiology
  Gragnoli Claudia, CHOP T/C and C/T haplotypes contribute to early-onset type 2 diabetes in Italians
  217:2, p. 291 - 295 2008
• Journal of Cellular Physiology
  Jonnakuty Catherine, etal What do we know about serotonin?
  217:2, p. 301 - 306 2008
• Journal of Cellular Physiology
  Gragnoli Claudia, The CM cell line derived from liver metastasis of malignant human insulinoma is not a valid beta cell model for in vitro studies
  216:2, p. 569 - 570 2008
• Journal of Cellular Physiology
  Jonnakuty Catherine, etal Karyotype of the human insulinoma CM cell line - Beta cell model in vitro?
  213:3, p. 661 - 662 2007
• Journal of Cellular Physiology
  Gragnoli Claudia, etal Linkage studies for T2D in chop and C/EBPbeta chromosomal regions in Italians
  213:2, p. 552 - 555 2007
• Journal of Cellular Physiology
  Gragnoli C., etal PSMD9 gene variants within NIDDM2 may rarely contribute to type 2 diabetes
  212:3, p. 568 - 571 2007
• Obesity and metabolism
  Gragnoli Claudia, etal PPAR gamma P12A variant in type 2 diabetes in Italians
  3:3, p. 99 - 100 2007
• Obesity and metabolism
  Gragnoli Claudia, Kir6.2 (KCNJ11) E23K variant in Type 2 diabetes in Italians
  3:2, p. 97 - 98 2007
• Minerva Medica
  Gragnoli C., etal Meta-analysis of the IPF1 D76N polymorphism in a worldwide type 2 diabetes population
  98:3, p. 163 - 166 2007
• Obesity and metabolism
  Milord Edrice, etal Chromosome 10 locus in linkage to type 2 diabetes in Italians
  3:1, p. 44 - 47 2007
• Minerva Medica
  Milord E., etal NEUROG3 variants and type 2 diabetes in Italians
  97:5, p. 373 - 378 2006
• Metabolism: Clinical and Experimental
  Gragnoli Claudia, etal IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetes
  54:8, p. 983 - 988 2005
• Metabolism: Clinical and Experimental
  Gragnoli Claudio, etal Linkage study of the glucagon receptor gene with type 2 diabetes mellitus in Italians
  54:6, p. 786 - 787 2005
• Metabolism: Clinical and Experimental
  Gragnoli Claudia, etal Triple genetic variation in the HNF-4α gene is associated with early-onset type 2 diabetes mellitus in a Philippino family
  53:8, p. 959 - 963 2004
• Diabetologia
  Gragnoli C., etal Early-onset Type II diabetes mellitus in Italian families due to mutations in the genes encoding hepatic nuclear factor 1α and glucokinase
  44:10, p. 1326 - 1329 2001
• Human mutation
  Godart François, etal Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1α (TCF1) promoter region in MODY patients
  15:2, p. 173 - 180 2000
• Diabetes
  Gragnoli Claudia, etal Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4α binding site in the promoter of the hepatocyte nuclear factor-1α gene
  46:10, p. 1648 - 1651 1997
• Journal of Clinical Investigation
  Lindner Tom, etal Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4α/MODY1 gene
  100:6, p. 1400 - 1405 1997
• Diabetes
  Lindner Tom, etal The 31-cM region of chromosome 11 including the obesity gene tubby and ATP-sensitive potassium channel genes, SUR1 and Kir6.2, Does not contain a major susceptibility locus for NIDDM in 127 non-hispanic white affected sibships
  46:7, p. 1227 - 1229 1997
• Diabetologia
  Pozzilli P., etal Double blind trial of nicotinamide in recent-onset IDDM (the IMDIAB III study)
  38:7, p. 848 - 852 1995
• Journal of Endocrinology
  Pozzilli P., etal New and old trends for treating organ-specific autoimmune endocrinopathies
  145:2, p. 195 - 199 1995
• Human Genetics
  Baroni Marco G., etal Affected sib-pair analysis of the GLUT1 glucose transporter gene locus in non-insulin-dependent diabetes mellitus (NIDDM)
  93:6, p. 675 - 680 1994
• Acta Therapeutica
  Baroni M. G., etal Therapy with a thymic extract and reduced recurrence of low urinary tract infections in patients with diabetes mellitus
  19:3, p. 283 - 294 1993

Presentations

• Amin M and Gragnoli C. Genome-Wide Linkage and Association Study Identifies Novel Genes and Pathways Implicated in Polycystic Ovarian Syndrome. European Society of Human Genetics Hybrid Meeting, Glasgow, Scotland, UK, June10-13, 2023, submitted 2023
• del Bosque-Plata L, Amin M, Wu R, Postolache T, and Gragnoli C. Novel TCF7L2 Familial Linkage and Association with Type 2 Diabetes, Depression, and Their Comorbidity. European Society of Human Genetics Hybrid Meeting, Glasgow, Scotland, UK, June10-13, 2023, submitted 2023
• Amin M, del Bosque-Plata L, Gonzalez-Ramirez R, Wu R, Postolache TT, Vergare M, Gordon, Ott J, PhD, and Gragnoli C. CRHR1 Gene Shows Extensive Linkage to Major Depression and Type 2 Diabetes in Italian families. Endocrine Society 2022, Atlanta, GA-June 11-14, 2022 2022
• Amin M, Ott J, Wu R, Postolache T, Vergare M, Gragnoli C. Comorbidity of CRHR2 Gene Variants in Type 2 Diabetes and Depression. 30th European Congress of Psychiatry (EPA), Budapest, Hungary-April 2-5, 2022 2022
• Amin M, Ott J, Wu R, Postolache T, Vergare M, Gragnoli C. Association of CRHR2 Gene Variants with Type 2 Diabetes and Depression. Psych Congress Europe 2022, Barcelona, Spain-February 23-25, 2022 2022
• Leadership Speaker Series, CUSOM 2022
• Invited speakers for Endocrine Grand Round and Medicine Grand Round to present on R adiofrequency Ablation (RFA) Technique used to cure benign thyroid nodules andm alignant thyroid nodules 2021