Laura A . Hansen, PhD

Department

Biomedical Sciences

Position

Professor

Book, Chapter/Section

• Reference Module in Biomedical Sciences
  Hansen Laura A., Squamous Cell Carcinoma of the Skin [Book Chapter] 2015
• Reference Module in Biomedical Research
  Hansen Laura A., Melanoma [Book Chapter] 2014
• Reference Module in Biomedical Research
  Hansen Laura A., Mycosis Fungoides [Book Chapter] 2014
• xPharm: The Comprehensive Pharmacology Reference
  Hansen Laura A., Skin Cancer [Book Chapter] 2011
• xPharm: The Comprehensive Pharmacology Reference
  Hansen Laura A., Mycosis Fungoides [Book Chapter] 2011
• xPharm: The Comprehensive Pharmacology Reference
  Hansen Laura A., Squamous Cell Carcinoma [Book Chapter] 2011
• xPharm: The Comprehensive Pharmacology Reference
  Hansen Laura A., Basal Cell Carcinoma [Book Chapter] 2011
• xPharm: The Comprehensive Pharmacology Reference
  Hansen Laura A., Melanoma [Book Chapter] 2011

Publications

• BioEssays
  Rudd Justin C, Hansen Laura A, Flower Delivery: The Emergence of FLOWER (FWE) as a Multifunctional Regulator of Endo-Lysosome-Related Organelle Trafficking Across Cell Types
  48:8, p. e70167 2026
• Cancer research (Chicago, Ill.)
  Islam Moynul, Monga Louise, Grunkemeyer James, Hansen Laura, Rudd Justin, Abstract 5734: Targeting exportin 1 reduces cutaneous squamous cell carcinoma growth alone and in combination with 5-fluorouracil
  86:7_Supplement, p. 5734 - 5734 2026
• Cancer research (Chicago, Ill.)
  Rudd Justin C., Kuwong Patrick T., Johnson Rachel E., Monga-Wells Louise N., Vo Meghan, Russolillo Julia, Reddy Shreya, Jacob Mallory, Litz Hunter, Li Changzhao, Siref Andrew, Grunkemeyer James A., Hansen Laura A., Abstract 3334: The human Flower isoform hFWE4 facilitates cornification in cutaneous squamous cell carcinoma
  86:7_Supplement, p. 3334 - 3334 2026
• JID innovations
  Rudd Justin C., Kuwong Patrick T., Johnson Rachel E., Monga-Wells Louise N., Vo Meghan, Russolillo Julia, Reddy Shreya, Jacob Mallory, Litz Hunter, Li Changzhao, Siref Andrew, Grunkemeyer James A., Hansen Laura A., The human Flower isoform hFWE4 facilitates cornification in cutaneous squamous cell carcinoma, p. 100468 2026
• Nature communications
  Rudd Justin C., Grunkemeyer James A., Madson Justin G., Sarkar Mrinal K., van den Bogaard Ellen H., Gudjonsson Johann E., Hansen Laura A., Smits Jos P. H., Kuwong Patrick T., Wong Sunny Y., Simpson Cory L., Johnson Rachel E., Monga Louise M. N., van Vlijmen-Willems Ivonne M. J. J., Porter Greer L., Kumar Vikas, Halloran Peter O., Sharma Kanika, Schmidt Karina N., Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier
  16:1, p. 6892 2025
• FEBS letters
  Kamayirese Seraphine, Hansen Laura A., Lovas Sándor, Ligand recognition by 14‐3‐3 proteins requires negative charges but not necessarily phosphorylation 2025
• The Journal of pharmacology and experimental therapeutics
  Opere Catherine, Rai Anjali, Mhatre Susmit, Borgmeier John, Howe Christina, Grunkemeyer James, Hansen Laura, Mbye Ya Fatou Njie, Ohia Sunny, Singh Somnath, Regulation of IOP and Retinal Degeneration by GYY 4137 in Carbomer-Induced OHT Rabbits, In vivo
  389, p. 530 - 530 2024
• International journal of molecular sciences
  Kamayirese Seraphine, Maity Sibaprasad, Hansen Laura A, Lovas Sándor, The Development of CDC25A-Derived Phosphoseryl Peptides That Bind 14-3-3ε with High Affinities
  25:9, p. 4918 2024
• ACS omega
  Kamayirese Seraphine, Dieckman Lynne M., Hansen Laura A., Lovas Sándor, Maity Sibaprasad, Optimizing Phosphopeptide Structures That Target 14-3-3ε in Cutaneous Squamous Cell Carcinoma 2024
• Biophysical journal
  Nichols Michael G., Farr Tyler B., Hubbs Hayden M., Snyder Dan R., Tran Thien, Varghese George J., Kalhorn Connor J., Myers Cecilia M., Nguyen Alicia C., Rogers Samuel J., Wood Daniel, Pham Dan L., Hansen Laura A., Impact of cell culture conditions on assessment of cellular metabolism in vitro by NAD(P)H phasor flim with application to in vivo diagnostic imaging for non-invasive biopsy
  121:3, p. 276a - 276a 2022
• Journal of biomedical optics
  Pham Dan L, Miller Christina R, Myers Molly S, Myers Dominick M, Hansen Laura A, Nichols Michael G, Development and characterization of phasor-based analysis for FLIM to evaluate the metabolic and epigenetic impact of HER2 inhibition on Squamous Cell Carcinoma (SCC) cultures
  26:10 2021
• Journal of Biomedical Optics
  Pham Dan L., Miller Christina R., Myers Molly S., Myers Dominick M., Hansen Laura A., Nichols Michael G., Development and characterization of phasor-based analysis for FLIM to evaluate the metabolic and epigenetic impact of HER2 inhibition on squamous cell carcinoma cultures
  26:10 2021
• Oncotarget
  Holmes Thomas R., Al-Matouq Jenan, Holmes Matti, Nicola Lauren, Rudd Justin C., Lovas Sándor, Hansen Laura A., Targeting 14-3-3ε-CDC25A interactions to trigger apoptotic cell death in skin cancer
  11:35, p. 3267 - 3278 2020
• Journal of Dermatological Science
  Lobl Marissa B., Clarey Dillon, Higgins Shauna, Sutton Adam, Hansen Laura, Wysong Ashley, Targeted next-generation sequencing of matched localized and metastatic primary high-risk SCCs identifies driver and co-occurring mutations and novel therapeutic targets
  99:1, p. 30 - 43 2020
• Biophysical journal
  Nichols Michael G., Huerter Ben G., Myers Molly, Myers Dominick, Jackson Kelsey A., Nguyen Duyen, Kalhorn Connor J., Varghese George, Sotelo Katie D., Frances Gabriel Marifel, Hansen Laura A., Che Dan L., Altuzar Emiliano, Long Anya, Morris Jackson W., Phasor-FLIM Quantification of Changes in Keratinocyte Metabolism and Tissue Architecture in a Longitudinal Study of UV-induced Skin Cancer
  118:3, p. 307a - 307a 2020
• Molecular Carcinogenesis
  Al-Matouq Jenan, Holmes Thomas R., Hansen Laura A., CDC25B and CDC25C overexpression in nonmelanoma skin cancer suppresses cell death
  58:9, p. 1691 - 1700 2019
• Molecular Carcinogenesis
  Holmes Thomas R., Dindu Shravya, Hansen Laura A., Aberrant localization of signaling proteins in skin cancer
  58:9, p. 1631 - 1639 2019
• Nature
  Madan Esha, Moreno Eduardo, Fazio Kimberly, Pelham Christopher J., Nagane Masaki, Parker Taylor M., Canas-Marques Rita, Shaik Kranti, Yuan Youzhong, Henriques Vanessa, Galzerano Antonio, Camacho Denise, Yamashita Tadashi, Pinto Miguel Alexandre Ferreira, Palma Antonio M., Vieira Ana, Soldini David, Nakshatri Harikrishna, Post Steven R., Yamashita Hiroko, Rhiner Christa, Accardi Davide, Hansen Laura A., Carvalho Carlos, Beltran Antonio L., Kuppusamy Periannan, Gogna Rajan, Flower isoforms promote competitive growth in cancer
  572:7768, p. 260 - 264 2019
• Biophysical journal
  Myers Dominick, Nguyen Duyen, Hansen Laura A., Nichols Michael G., Yang Brooke L., Sotelo Katie D., Huerter Ben G., Che Dan L., Myers Molly, Frances Gabriel Marifel, Jackson Kelsey A., Two-Photon Imaging of NADH in SKH1 Mice Reveals Changes in Keratinocyte Metabolism with Chronic UVA Exposure
  116:3, p. 281a - 282a 2019
• Cancer research (Chicago, Ill.)
  Holmes Thomas R., Nicholson Yawah T., Al-Matouq Jenan, Hammiller Brianna, Holmes Matti J., Hansen Laura A., Abstract LB-190: CDC25A suppression of apoptosis in cutaneous squamous cell carcinoma depends on 14-3-3ϵ
  78:13_Supplement, p. LB-190 - LB-190 2018
• Experimental Dermatology
  Bichsel Kyle J., Hansen Laura A., Hammiller Brianna O., Trempus C. S., Li Y., The Epidermal Growth Factor Receptor Decreases Stathmin 1 and Triggers Catagen Entry in the Mouse
  25:4, p. 275 - 281 2016
• Molecular Carcinogenesis
  Rao Velidi H., Yanagida Jodi K., Vogel Kristen, Marwaha Nitin, Kandel Amrit, Trempus C., Repertinger Susan K., Hansen Laura A., Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression
  54:10, p. 1026 - 1036 2015
• Frontiers in Oncology
  Hammiller Brianna O., El-Abaseri Taghrid B., Dlugosz A. A., Hansen Laura A., A Method for the Immortalization of Newborn Mouse Skin Keratinocytes
  5, p. (9 pages) 2015
• Journal of Dermatological Science
  Shirley Stephanie H., Hammiller Brianna O., Hudson Laurie G., Kusewitt Donna F., Crysup Benjamin, Hansen Laura A., Role of the Epidermal Growth Factor Receptor in Ultraviolet Radiation Induction of Snail Family Transcription Factors
  76:2, p. 149 - 151 2014
• Cancer research (Chicago, Ill.)
  Almatouq Jenan, Ho Kristen, Hansen Laura A., Abstract 1310: Increased cytoplasmic CDC25A phosphatase in cutaneous squamous cell carcinoma leads to 14-3-3 relocalization and suppression of apoptosis
  74:19_Supplement, p. 1310 - 1310 2014
• Molecular Carcinogenesis
  Rao Velidi H., Marwaha Nitin, Vogel Kristen, Yanagida Jodi K., Kandel Amrit, Trempus Carol, Repertinger Susan K., Hansen Laura A., Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression
  ePub ahead of print, p. 11 pages 2014
• ISRN Dermatology
  El-Abaseri Taghrid Bahig, Hansen Laura A., Hammiller Brianna, Repertinger Susan K., The Epidermal Growth Factor Receptor Increases Cytokine Production and Cutaneous Inflammation in Response to Ultraviolet Irradiation
  2013, p. 1 - 11 2013
• Cancer research (Chicago, Ill.)
  Bichsel Kyle J., Hansen Laura A., Gaulter Jessica A., Porto Dennis, Foote Courtney, Abstract 1219: Defective catagen entry in EGFR deficient skin precedes cutaneous inflammation
  72:8_Supplement, p. 1219 - 1219 2012
• Oncogene
  Rao Velidi H., Deng Cai-Shu, Lynch David T., Pena Zachary G., Marwaha Nitin, Watson Patrice, Kandel Amrit, Hansen Laura A., A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion
  31:23, p. 2888 - 2898 2012
• Carcinogenesis
  Yanagida J., Behrens M., Hammiller B., Al-Matouq J., Trempus C. S., Repertinger Susan K., Hansen Laura A., Accelerated elimination of ultraviolet-induced DNA damage through apoptosis in CDC25A deficient skin
  33:9, p. 1754 - 1761 2012
• The FASEB journal
  Trotter Caitlyn, Maklad Adel, Hansen Laura, Conway Marianne, Evidence for critical period in development of cutaneous innervation: A study in nude mice
  25:S1, p. lb29 - lb29 2011
• Anatomical Record
  Maklad Adel, Conway Marianne, Hodges Cole, Hansen Laura A., Development of innervation to maxillary whiskers in mice
  293:9, p. 1553 - 1567 2010
• Molecular Carcinogenesis
  Virador Victoria M., Strain Kathryn, Yuspa Stuart H., Anders Joanna, Cataisson Christophe, Hansen Laura A., Zakhari Julia, Flores-Obando Rafael E., Berry Adam, Patel Rinal, Lo Yu Chien, The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis
  48:7, p. 599 - 609 2009
• Molecular Carcinogenesis
  Virador Victoria M., Patel Rinal, Flores-Obando Rafael E., Berry Adam, Hansen Laura A., Yuspa Stuart H., Cataisson Christophe, Zakhari Julia, Lo Yu-Chien, Strain Kathryn, Anders Joanna, The Human Promyelocytic Leukemia Protein Is a Tumor Suppressor for Murine Skin Carcinogenesis
  48:7, p. 599 - 609 2009
• Journal of Investigative Dermatology
  Maklad Adel, Evenson Jackie E., Nicolai Jodi R., Bichsel Kyle J., Lee Tang-Cheng, Threadgill David W., Hansen Laura A., The EGFR Is Required for Proper Innervation to the Skin
  129:3, p. 690 - 698 2009
• Toxicologic pathology
  Lynch Dave, Hofland Hans E.J., Svoboda Jessica, Putta Sumanth, Chern Wendy H., Hansen Laura A., Mouse skin models for carcinogenic hazard identification
  35:7, p. 853 - 864 2007
• Pediatric Dermatology
  Hornung R. L., Lipsky M. S., Hansen Laura A., Sharp L. K., Poorsattar S. P., Skin cancer prevention in the primary care setting: assessment using a standardized patient
  24:2, p. 108 - 112 2007
• Toxicologic Pathology
  Lynch Dave, Putta Sumanth, Svoboda Jessica, Hofland Hans E. J., Chern Wendy H., Hansen Laura A., Mouse skin models for carcinogenic hazard identification: utilities and challenges
  35:7, p. 853 - 864 2007
• Journal of Biomedicine and Biotechnology
  El-Abaseri Taghrid B., Hansen Laura A., EGFR activation and ultraviolet light-induced skin carcinogenesis, p. 97939 2007
• BioEssays
  Fritzsch Bernd, Beisel Kirk W., Hansen Laura A., The molecular basis of neurosensory cell formation in ear development: a blueprint for hair cell and sensory neuron regeneration?
  28:12, p. 1181 - 1193 2006
• American Journal of Pathology
  Madson Justin G., Putta Sumanth K., Lynch David T., Tinkum Kelsy L., Hansen Laura A., Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation
  169:4, p. 1402 - 1414 2006
• Brain Research
  Morris Jacqueline K., Sorensen Christian, Lee Kuo Fen, Macklin Wendy B., Fritzsch Bernd, Maklad Adel, Hansen Laura A., Feng Feng, A disorganized innervation of the inner ear persists in the absence of ErbB2
  1091:1, p. 186 - 199 2006
• Lung cancer (Amsterdam, Netherlands)
  Jensen R., Spang-Thomsen M., Hansen L., P-057 Expression of the cyclin-dependent kinase inhibitor p21 is linkedto regulation of RAD51 in response to etoposide treatment of small cell lung cancer cells
  49, p. S129 - S129 2005
• Cancer Research
  El-Abaseri Taghrid B., Tennant R. W., Hansen Laura A., Shendrik I., Trempus C., Fuhrman Jill, Chemoprevention of UV light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor.
  65:9, p. 3958 - 3965 2005
• Journal of Investigative Dermatology
  Repertinger Susan K., Hansen Laura A., Yuspa S. H., Campagnaro E., Fuhrman Jill, El-Abaseri Taghrid B., EGFR enhances early healing after cutaneous incisional wounding
  123:5, p. 982 - 989 2004
• Pharmacotherapy
  Snella Kathleen A., Trewyn Rence R., Hansen Laura A., Bradberry J. Chris, Pharmacist Compensation for Cognitive Services: Focus on the Physician Office and Community Pharmacy
  24:3, p. 372 - 388 2004
• Cell and Tissue Research
  Maklad Adel, Fritzsch Bernd, Hansen Laura A., Innervation of the maxillary vibrissae in mice as revealed by anterograde and retrograde tract tracing
  315:2, p. 167 - 180 2004
• Cancer Research
  Hansen Laura A., Virador V., Brown D., Tanaka T., Andreola F., Strain K., Dancheck B., Riley R., Arbeit J. M., De Luca L. M., Kogan S., Yuspa S. H., A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis
  63:17, p. 5257 - 5265 2003
• Oncogene
  Seker Hasan, Bowman Elise D., Rubbi Carlos, Linke Steven P., Garfield Susan, Hansen Laura, Borden Katherine L.B., Milner Jo, Harris Curtis C., UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML
  22:11, p. 1620 - 1628 2003
• Molecules and cells
  Chi Y, OH B, Frantz J, Hansen L, Shoelson S, , DIABETES MUTATIONS DELINEATE AN ATYPICAL POU DOMAIN IN HNF1A
  10 2002
• Cancer research
  Hansen L A, Strain K, Woodson R L, Holbus S, Lo Y C, Yuspa S H, The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors
  60:13, p. 3328 - 3332 2000
• Carcinogenesis
  Hansen Laura A., Ross Sharon A., Sigman Caroline C., Andreola Fausto, Kelloff Gary J., De Luca Luigi M., Retinoids in chemoprevention and differentiation therapy
  21:7, p. 1271 - 1279 2000
• Carcinogenesis
  Hansen Laura A., Rosenberg Michael, Malarkey David E., Wilkinson J. Erby, Woychik Richard E., Tennant Raymond W., Effect of the viable-yellow (A(vy)) agouti allele on skin tumorigenesis and humoral hypercalcemia in v-Ha-ras transgenic TG.AC mice
  19:10, p. 1837 - 1845 1998
• Experimental Cell Research
  Saitoh Atsushi, Hansen Laura A., Vogel Jonathan C., Udey Mark C., Characterization of Wnt gene expression in murine skin
  243:1, p. 150 - 160 1998
• Genes and Development
  Robles Ana I., Sicinski Piotr, Rodriguez-Puebla Marcelo L., Glick Adam B., Trempus Carol, Hansen Laura, Tennant Raymond W., Weinberg Robert A., Yuspa Stuart H., Conti Claudio J., Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo
  12:16, p. 2469 - 2474 1998
• Cancer Research
  Tennenbaum Tamar, Hansen Laura, Morgan David L., Lowry David, Darwiche Nadine, Gartsbein Marina, De Luca Luigi M., Hennings Henry, Yuspa Stuart H., Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion
  58:7, p. 1435 - 1443 1998
• Toxicologic pathology
  Humble Michael C., Spalding Judson W., Szczesniak Carl J., Luetteke Noreen C., Cannon Ronald E., Hansen Laura A., Lee David C., Tennant Raymond W., TGFα is dispensable for skin tumorigenesis in Tg.AC mice
  26:4, p. 562 - 569 1998
• American Journal of Pathology
  Hansen Laura A., Sundberg John P., Alexander Natalie, Hogan Margaret E., Dlugosz Andrzej, Threadgill David W., Magnuson Terry, Yuspa Stuart H., Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development
  150:6, p. 1959 - 1975 1997
• Carcinogenesis
  Hansen Laura A., Tennant Raymond W., Trempus Carol S., Mahler Joel F., Association of tumor development with increased cellular proliferation and transgene overexpression, but not c-Ha-ras mutations, in v-Ha-ras transgenic Tg.AC mice
  17:9, p. 1825 - 1833 1996
• Science (American Association for the Advancement of Science)
  Threadgill David W, Hansen Laura A, Tennenbaum Tamar, Lichti Urike, Yee Della, LaMantia Christian, Mourton Tracy, Herrup Karl, Harris Raymond C, Magnuson Terry, Barnard John A, Yuspa Stuart H, Coffey Robert J, Dlugosz Andrzej A, Targeted distribution of mouse EGF receptor: effect of genetic background on mutant phenotype.(epidermal growth factor receptor)
  269:5221, p. 230 1995
• Progress in clinical and biological research
  Hansen L. A., French J. E., Tennant R. W., Spalding J. W., A transgenic mouse model (TG.AC) for skin carcinogenesis
  391, p. 223 - 235 1995
• Science
  Threadgill David W., Mourton Tracy, Coffey Robert J., Magnuson Terry, Yee Della, LaMantia Christian, Herrup Karl, Harris Raymond C., Barnard John A., Yuspa Stuart H., Tennenbaum Tamar, Dlugosz Andrzej A., Hansen Laura A., Lichti Ulrike, Targeted disruption of mouse EGF receptor
  269:5221, p. 230 - 234 1995
• Molecular Carcinogenesis
  French John E., Libbus Bisharah L., Mahler Joel, Hansen Laura, Spalding Judson, Tice Raymond R., Tennant Raymond W., Cytogenetic analysis of malignant skin tumors induced in chemically treated TG.AC transgenic mice
  11:4, p. 215 - 226 1994
• Proceedings of the National Academy of Sciences - PNAS
  Hansen Laura, Tennant Raymond, Follicular origin of epidermal papillomas in v-Ha-ras transgenic TC.AC mouse skin
  91:16, p. 7822 1994
• Mutagenesis
  Tennant Raymond W., Hansen Laura, Spalding Judson, Gene manipulation and genetic toxicology
  9:3, p. 171 - 174 1994
• Cancer genetics and cytogenetics
  Libbus Bisharah L., Tennant Raymond W., French John E., Spalding Judson, Hansen Laura, Tice Raymond R., Highly repetitive chromosome changes associated with skin tumor development in transgenic mice treated with TPA
  66:2, p. 152 - 152 1993
• Cancer Research
  Hansen Laura A., Monteiro-Riviere Nancy A., Smart Robert C., Differential Down-Regulation of Epidermal Protein Kinase C by 12–O-Tetradecanoylphorbol-13-acetate and Diacylglycerol
  50:18, p. 5740 - 5745 1990
• Breast cancer research and treatment
  SPANG-THOMSEN M, Vindeløv L. L, Rygaard K, Hansen L, Halvorsen A.-C, Brunner N, Growth kinetics of four human breast carcinomas grown in nude mice
  14:2, p. 235 - 243 1989
• Cancer Research
  Smart Robert C., Hansen Laura A., Conney Allan H., Mills Kevin J., Synthetic Lipid Second Messenger sn-1,2-Didecanoylglycerol
  49:16, p. 4455 - 4458 1989