David Zhi-Zhou He, MD, PhD

Department

Biomedical Sciences

Position

Professor

Book, Chapter/Section

• The Senses: A Comprehensive Reference
  Beisel K.W., He D., Hallworth R., Fritzsch B., Genetics of mechanoreceptor evolution and development [Book Chapter] 2008
• Audition
  Beisel K. W., He D., Fritzsch B., Hallworth R., Genetics of Mechanoreceptor Evolution and Development [Book Chapter] 2008

General

• Cheatham Mary Ann, Fritzsch Bernd, He David Z., Walters Bradley J., Editorial: Hair cells: From molecules to function, volume II 2022
• He David Z, Liu Ke, Sun Wei, Zhou Xiaoming, Bao Shaowen, Gong Shusheng, He David Z., Editorial: Hearing Loss and Cognitive Disorders 2022
• Walters Brad, He David Z., Cheatham Mary Ann, Fritzsch Bernd, Hair Cells: From Molecules to Function, Volume II 2022

Publications

• Advanced science
  Kulasooriya Samadhi, Liu Huizhan, Vijayakumar Sarath, Bloom Celia, Xu Zhenhang, Tu Shu, Borgmeier Benjamin J, Zhou Mi, Tao Litao, Kachar Bechara, He David Z, Molecular and Cellular Hallmarks of Age-Related Vestibular Hair Cell Degeneration, p. e76340 2026
• eLife
  Xu Zhanhong, Tao Litao, Tavakoli Amirrasoul, Kulasooriya Samadhi, Liu Huizhan, Tu Shu, Bloom Celia, Li Yi, Johnson Tirone D., Zuo Jian, Kachar Bechara, He David Z., The dual molecular identity of vestibular kinocilia bridges structural and functional traits of primary and motile cilia
  14 2026
• Frontiers in cell and developmental biology
  Renauld Justine M., Weng Xin, Qin Tianli, Sham Mai Har, Chizhikov Victor V., Fritzsch Bernd, Iskusnykh Igor Y., Yamoah Ebenezer N., Smith Richard J. H., Affortit Corentin, He David Z., Liu Huizhan, Nichols David, Bouma Judith, Nayak Mahesh K., Correction: Lmx1a is essential for marginal cell differentiation and stria vascularis formation
  14 2026
• Frontiers in cell and developmental biology
  Renauld Justine M., Iskusnykh Igor Y., Yamoah Ebenezer N., Smith Richard J. H., Weng Xin, Qin Tianli, Sham Mai Har, Chizhikov Victor V., Fritzsch Bernd, Bouma Judith, Nayak Mahesh K., Affortit Corentin, He David Z., Liu Huizhan, Nichols David, Lmx1a is essential for marginal cell differentiation and stria vascularis formation
  13 2025
• Hearing research
  Ma XianHua, Han Shuang, Zhang Yuqing, Sun Lianhua, Qu Jiaxi, Ying Hao, Chen Yuxia, Tang Jie, He David Z., Zhang Weiping J., Xie Zhifang, Wei Chunchun, Jiang Fei, Thyroid Hormone Signaling is Essential for the Maturation and Survival of Cochlear Root Cells in Mice, p. 109222 2025
• Frontiers in neurology
  Giffen Kimberlee P., Chen Lei, Kramer Kenneth L., Li Yi, Zallocchi Marisa, Liu Huizhan, Yamane Kacey L., He David Z., Molecular specializations underlying phenotypic differences in inner ear hair cells of zebrafish and mice
  15 2024
• Science translational medicine
  He David Z, Vijayakumar Sarath, Fleegel Jonathan P., Batalkina Lyudmila, Brunette Katyarina E., Shukal Dhaval, Chen Zhiyong, Devuyst Olivier, Liu Huizhan, He David Z. Z., Imami Ali Sajid, Hamoud Abdul-Rizaq Ali, McCullumsmith Robert E, Conda-Sheridan Martin, De Campos Luana Janaina, Zuo Jian, Zallocchi Marisa, Piplartine attenuates aminoglycoside-induced TRPV1 activity and protects from hearing loss in mice
  16:759, p. eadn2140 2024
• Frontiers in neurology
  Wang Tianying, Liu Huizhan, He David Z., Li Yi, Occlusion of two semicircular canals does not disrupt normal hearing in adult mice
  13, p. 997367 - 997367 2022
• Frontiers in cellular neuroscience
  Xu Zhenhang, Tu Shu, Zuo Jian, Pass Caroline, Zhang Yan, Liu Huizhan, Diers Jack, Fu Yusi, He David Z. Z., Profiling mouse cochlear cell maturation using 10x Genomics single-cell transcriptomics
  16 2022
• Cell Reports
  Liu Huizhan, Giffen Kimberlee P., Kozeny Grant A., Chen Lei, Henderson Heidi J., Cao Talia A., Beisel Kirk, Li Yi, He David Z., Molecular and cytological profiling of biological aging of mouse cochlear inner and outer hair cells
  39:2 2022
• Science Advances
  Giffen Kimberlee P., Zhao Xiao Chang, He David Z., Li Yi, Liu Huizhan, Janesick Amanda, Zhang Chang Jun, Shen Ren Juan, Wang Tianying, Chen Bo Bei, Gong Shu Sheng, Kachar Bechara, Jin Zi Bing, Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction
  8:14 2022
• BMC Neuroscience
  Zu Mian, Shi Wei Guo, Yang Shi Ming, Sun Wei, Guo Wei Wei, Cong Tao, Ji Fei, Zhang Shi Li, Zhang Yue, Song Xin, He David Z.Z., SCN11A gene deletion causes sensorineural hearing loss by impairing the ribbon synapses and auditory nerves
  22:1 2021
• Frontiers in Cellular Neuroscience
  Qi Yue, Li Yi, Wei Wei, Zhang Lingjun, Liu Ke, He David Z., Gong Shusheng, Du Zhengde, Xiong Wei, Yu Shukui, Qu Tengfei, He Lu, Deletion of C1ql1 Causes Hearing Loss and Abnormal Auditory Nerve Fibers in the Mouse Cochlea
  15 2021
• Cell and Tissue Research
  Nichols David H., Fritzsch Bernd, Beisel Kirk W., He David Z.Z., Liu Huizhan, Bouma Judith E., Kopecky Benjamin J., Jahan Israt, Interaction with ectopic cochlear crista sensory epithelium disrupts basal cochlear sensory epithelium development in Lmx1a mutant mice
  380:3, p. 435 - 448 2020
• Frontiers in Neuroscience
  Giffen Kimberlee P., Kramer Kenneth L., He David Z., Liu Huizhan, Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells
  13 2019
• Scientific reports
  Rocha-Sanchez Sonia M., Fuson Olivia, Tarang Shikha, Goodman Linda, Pyakurel Umesh, Liu Huizhan, He David Z., Zallocchi Marisa, Quinoxaline protects zebrafish lateral line hair cells from cisplatin and aminoglycosides damage (vol 8, 15119, 2018)
  9 2019
• The FASEB journal
  Morrill Seth, He David, The Effects of Bcl6 KO in Mouse Cochlear Hair Cells
  33:S1, p. 610.14 - 610.14 2019
• The FASEB Journal
  Giffen Kimberlee, Kramer Kenneth, Liu Huizhan, He David, Characterizing the Role of Kcnq5a in Zebrafish Inner Ear Hair Cells
  33:S1 2019
• Cell Reports
  Ranum Paul T., Walls William D., Koh Jin Young, He David Z.Z., Smith Richard J.H., Goodwin Alexander T., Yoshimura Hidekane, Kolbe Diana L., Insights into the Biology of Hearing and Deafness Revealed by Single-Cell RNA Sequencing
  26:11, p. 3160 - 3171.e3 2019
• Frontiers in Molecular Neuroscience
  Liu Huizhan, Stringham Sean T., Chen Lei, Giffen Kimberlee P., Li Yi, Judge Paul D., Beisel Kirk W., He David Z.Z., Cell-Specific Transcriptome Analysis Shows That Adult Pillar and Deiters' Cells Express Genes Encoding Machinery for Specializations of Cochlear Hair Cells
  11 2018
• Frontiers in Molecular Neuroscience
  Hu Qun, Guo Li, Song Chenmeng, Li Jie, Yu Lisheng, He David Z.Z., Xiong Wei, Deletion of Kncn Does Not Affect Kinocilium and Stereocilia Bundle Morphogenesis and Mechanotransduction in Cochlear Hair Cells
  11 2018
• Scientific Data
  Barta Cody L., Chen Lei, Giffen Kimberlee P., Li Yi, Kramer Kenneth L., Beisel Kirk W., He David Z., Liu Huizhan, RNA-seq transcriptomic analysis of adult zebrafish inner ear hair cells
  5 2018
• Scientific Data
  Li Yi, Liu Huizhan, Giffen Kimberlee P., Chen Lei, Beisel Kirk W., He David Z.Z., Transcriptomes of cochlear inner and outer hair cells from adult mice
  5 2018
• Journal of Otology
  Morrill Seth, He David Z.Z., Apoptosis in inner ear sensory hair cells
  12:4, p. 151 - 164 2017
• Reproduction Fertility and Development
  Guo Weiwei, Ren Lili, Yi Haijin, Yan Zhang, Chen Lei, Zhao Li Dong, Ning Yu, He David Z. Z., Yang Shi-Ming, The Morphological and Functional Development of the Stria Vascularis in Miniature Pigs
  29:3, p. 585 - 593 2017
• PloS One
  Liu Huizhan, Nichols David H., Chen Lei, Zhang Qian, Pan N., Fritzsch B., He David Z. Z., Li Yi, Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?
  11:12 2016
• Plos One
  Li Yi, Beisel Kirk W., He David Z. Z., Zhang Weiping J., Gong Shusheng, Liu Huizhan, Barta Cody L., Zhao Lidong, Judge Paul D., Transcription Factors Expressed in Mouse Cochlear Inner and Outer Hair Cells
  11:3, p. e0151291 - e0151291 2016
• Journal of Biological Chemistry
  Lovas Sandor, He David Z. Z., Liu Huizhan, Tang Jie, Pecka Jason L., Hatfield Marcus P. D., Beisel Kirk W., Glutamate Transporter Homolog-based Model Predicts That Anion-pi Interaction Is the Mechanism for the Voltage-dependent Response of Prestin
  290:40, p. 24326 - 24339 2015
• PLoS One
  Zhang Qian, Liu Huizhan, Soukup Garrett A., He David Z. Z., Identifying microRNAs involved in aging of the lateral wall of the cochlear duct
  9:11, p. e112857 - e112857 2014
• Journal of Neuroscience
  Liu H., Pecka J. L., Zhang Q., Soukup G. A., He D. Z. Z., Beisel K. W., Characterization of transcriptomes of cochlear inner and outer hair cells
  34:33, p. 11085 - 11095 2014
• PLoS One
  Li Jun, Gong Shusheng, Liu Huizhan, Zhang Qian, He David Z. Z., Morphology and Ciliary Motion of Mucosa in the Eustachian Tube of Neonatal and Adult Gerbils
  9:6, p. e99840 2014
• Hearing Research
  He David Z. Z., Beisel Kirk W., Lovas Sandor, Li Yi, Ai Yu, Prestin at year 14: progress and prospect
  311, p. 25 - 35 2014
• PLoS One
  Mao Zhongping, Zhao Lijun, Pu Lichun, Wang Mingxiao, Zhang Qian, He David Z. Z., How Well Can Centenarians Hear?
  8:6, p. 1 - 7 2013
• PloS one
  Yang Shi Ming, Jia Shuping, Chen Wei, Guo Wei Wei, Sun Jian He, Liu Hui Zhan, Young Wie Yen, He David Z.Z., Regeneration of Stereocilia of Hair Cells by Forced Atoh1 Expression in the Adult Mammalian Cochlea
  7:9 2012
• Journal of Cell Science
  Tan Xiaodong, Pecka Jason L., Tang Jie, Lovas Sandor, Beisel Kirk W., He David Z. Z., A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin
  125:4, p. 1039 - 1047 2012
• PLoS One
  Yuan Yongyi, Guo Weiwei, Tang Jie, Zhang Xun, Wang Guojian, Han Mingyu, Dai Pu, He David Z. Z., Yang Shiming, Molecular Epidemiology and Functional Assessment of Novel Allelic Variants of SLC26A4 in Non-Syndromic Hearing Loss Patients with Enlarged Vestibular Aqueduct in China
  7:11, p. e49984 - e49984 2012
• International Journal of Developmental Neuroscience
  Yang Xiao, Sun Jian-he, Deng An-chun, Huang De-liang, Zhai Suo-qiang, Yu Ya-ping, Hou Zhao-hui, Guo Wei-wei, He David Z. Z., Han Dong-yi, Young Wie-yen, The role of Smad4 in vestibular development in mice
  29:1, p. 15 - 23 2011
• International Journal of Developmental Neuroscience
  Yang Xiao, He David Z. Z., Han Dong-yi, Young Wie-yen, Sun Jian-he, Yu Ya-ping, Hou Zhao-hui, Guo Wei-wei, Zhai Suo-qiang, Deng An-chun, Huang De-liang, Corrigendum to “The role of Smad4 in vestibular development in mice” [Int. J. Dev. Neurosci. 29 (2011) 15–23]
  29:7, p. 783 2011
• Journal of Neurophysiology
  Xiaodong Tan, Tan Xiaodong, Okoruwa Oseremen E., Zhang Qian, Beisel Kirk W., He David Z. Z., Tang Jie, Pecka Jason L., From Zebrafish to Mammal: Functional Evolution of Prestin, the Motor Protein of Cochlear Outer Hair Cells
  105:1, p. 36 - 44 2011
• American Journal of Respiratory Cell and Molecular Biology
  Jia Shuping, Gerson T. G., Wang Zhao-Yi, Casale Thomas B., He David Z. Z., Segal M., Berro A., Zhang X., Expression and Function of a Novel Variant of Estrogen Receptor-ER-{alpha}36 in Mouse Airway
  45:5, p. 1084 - 1089 2011
• Journal of Biological Chemistry
  Tang Jie, Pecka Jason L., Tan Xiaodong, Beisel Kirk W., He David Z. Z., Engineered pendrin: An anion transporter and molecular motor
  286:35, p. 31014 - 31021 2011
• Cytoskeleton
  He David Z.Z., Riordan Gavin P., Jia Shuping, Sato Takashi, Zuo Jian, Andrade Leonardo R., Kachar Bechara, Changes in plasma membrane structure and electromotile properties in prestin deficient outer hair cells
  67:1, p. 43 - 55 2010
• Brain Research
  Wang Xiang, Yang S., Jia Shuping, He David Z. Z., Prestin forms oligomer with four mechanically independent subunits
  1333, p. 28 - 35 2010
• Journal of Neuroscience
  Jia S., Yang S., Guo W., He D. Z. Z., Fate of mammalian cochlear hair cells and stereocilia after loss of the stereocilia
  29:48, p. 15277 - 15285 2009
• Biochemical and Biophysical Research Communications
  Kumano Shun, Tan Xiaodong, He David Z.Z., Iida Koji, Murakoshi Michio, Wada Hiroshi, Mutation-induced reinforcement of prestin-expressing cells
  389:4, p. 569 - 574 2009
• Developmental Dynamics
  Yang Xiao, Hou Zhao-hui, Zhang Ji-shuai, He David Z. Z., Hu Yin-yan, Sun Jian-he, Guo Wei-wei, Han Dong-yi, Young Wie-yen, Chondrocyte-Specific Smad4 Gene Conditional Knockout Results in Hearing Loss and Inner Ear Malformation in Mice
  238:8, p. 1897 - 1908 2009
• Developmental neurobiology (Hoboken, N.J.)
  Yang Shi-Ming, Guo Wei-Wei, Sun Yan-Xun, Hou Zhao-Hui, Wang Xiang, He David Z. Z., Zhai Suo-Qiang, Young Wie-Yen, Sun Jian-He, Hu Yin-Yan, Han Dong-Yi, Yang Xiao, Smad5 Haploinsufficiency Leads to Hair Cell and Hearing Loss
  69:2-3, p. 153 - 161 2009
• Developmental Dynamics
  Yang Shi Ming, Hou Zhao Hui, Yang Guan, Zhang Ji Shuai, Han Dong Yi, Hu Yin Yan, Sun Jian He, Guo Wei Wei, He David Z.Z., Young Wie Yen, Yang Xiao, Chondrocyte-specific Smad4 gene conditional knockout results in hearing loss and inner ear malformation in mice
  238:8, p. 1897 - 1908 2008
• Brain Research
  Wu Xudong, Dallos Peter, Yu Yiling, Jia Shuping, Zheng Jing, He David Z.Z., Cheatham Mary Ann, Wang Xiang, Gao Jiangang, Zuo Jian, Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification
  1210, p. 20 - 28 2008
• Neuron
  Dallos Peter, Wu Xudong, Cheatham Mary Ann, Gao Jiangang, Zheng Jing, Anderson Charles T., Jia Shuping, Wang Xiang, Cheng Wendy H.Y., Sengupta Soma, He David Z.Z., Zuo Jian, Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification
  58:3, p. 333 - 339 2008
• Brain Research
  Wu Xudong, Wang Xiang, Gao Jiangang, Yu Yiling, Jia Shuping, Zheng Jing, Dallos Peter, Zuo Jian, He David Z. Z., Cheatham MaryAnn, Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification
  1210, p. 20 - 28 2008
• Proceedings of the National Academy of Sciences of the United States of America
  Gao Jiangang, Aguinaga Sal, Wang Xiang, Zheng Jing, Wu Xudong, Huynh Kristin, Jia Shuping, Matsuda Keiji, Patel Manish, Cheatham Mary Ann, He David Z., Dallos Peter, Zuo Jian, Prestin-based outer hair cell electromotility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier
  104:30, p. 12542 - 12547 2007
• Journal of Physiology
  Albert J. T., Winter H., Schaechinger T. J., Weber T., Wang Xiang, Zimmermann U., Oelmann K., Knipper M., Gopfert M. C., Oliver D., Geisler H. S., He David Z. Z., Hendrich O., Voltage-sensitive prestin orthologue expressed in zebrafish hair cells
  580:Pt. 2, p. 451 - 461 2007
• Journal of Neuroscience
  Jia S., Dallos P., He D. Z. Z., Mechanoelectric transduction of adult inner hair cells
  27:5, p. 1006 - 1014 2007
• Journal of Neuroscience
  Jia Shuping, Dallos P., He David Z. Z., Mechanoelectric transduction of adult inner hair cells
  27:5, p. 1006 - 1014 2007
• The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME
  Murakoshi Michio, Wada Hiroshi, HE David Z. Z., Kumano Shun, Iida Koji, 109 Atomic Force Microscopic Observation of the Conformational Changes in the Voltage-dependent Motor Protein Prestin
  2005.18, p. 25 - 26 2006
• Journal of Membrane Biology
  He David Z. Z., Zheng J., Kalinec F., Kakehata S., Santos-Sacchi J., Tuning in to the amazing outer hair cell: Membrane wizardry with a twist and shout
  209:2/3, p. 119 - 134 2006
• Nature
  He David Z.Z., Jia Shuping, Dallas Peter, Mechanoelectrical transduction of adult outer hair cells studied in a gerbil hemicochlea
  429:6993, p. 766 - 770 2004
• Developmental Brain Research
  He David Z.Z., Vetter Douglas E., Cheatham Mary Ann, Pearce Malini, Mouse outer hair cells lacking the α9 ACh receptor are motile
  148:1, p. 19 - 25 2004
• Journal of Physiology
  He D. Z. Z., Ding D. L., Beisel K. W., Chen L., Jia S. P., Fritzsch Bernd, Salvi R., Chick hair cells do not exhibit voltage-dependent somatic motility
  546:2, p. 511 - 520 2003
• Journal of Physiology
  He David Z.Z., Beisel Kirk W., Chen Lin, Ding Da Lian, Jia Shuping, Fritzsch Bernd, Salvi Richard, Chick hair cells do not exhibit voltage-dependent somatic motility
  546:2, p. 511 - 520 2003
• Audiology and Neuro-Otology
  Zheng Jing, Cheng Jennifer, Long Kevin B., Robison Donald E., He David Z.Z., Dallos Peter, Madison Laird D., Identification of differentially expressed cDNA clones from gerbil cochlear outer hair cells
  7:5, p. 277 - 288 2002
• Brain Research
  Szönyi Magdolna, Dallos Peter, He David Z.Z., Ribári Ottó, Sziklai István, Intracellular calcium and outer hair cell electromotility
  922:1, p. 65 - 70 2001
• Science
  Oliver D., He D. Z.Z., Klöcker N., Ludwig J., Schulte U., Waldegger S., Ruppersberg J. P., Dallos P., Fakler B., Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein
  292:5525, p. 2340 - 2343 2001
• Nature
  Zheng Jing, Shen Weixing, He David Z.Z., Long Kevin B., Madison Laird D., Dallos Peter, Prestin is the motor protein of cochlear outer hair cells
  405:6783, p. 149 - 155 2000
• Proceedings of the National Academy of Sciences of the United States of America
  He D. Z.Z., Dallos P., Somatic stiffness of cochlear outer hair cells is voltage-dependent
  96:14, p. 8223 - 8228 1999
• Journal of Neurophysiology
  He David Z.Z., Dallos Peter, Development of acetylcholine-induced responses in neonatal gerbil outer hair cells
  81:3, p. 1162 - 1170 1999
• Developmental Brain Research
  He David Z.Z., Dallos Peter, Expression of potassium channels in gerbil outer hair cells during development does not require neural induction
  103:1, p. 95 - 97 1997
• Journal of Neuroscience
  He David Z.Z., Relationship between the development of outer hair cell electromotility and efferent innervation
  17:10, p. 3634 - 3643 1997
• ORL
  Liu Tien Chen, He David Z.Z., Lin Xi, A novel, simple organotypic culture method to study the organ of corti from the neonatal gerbil
  59:5, p. 243 - 247 1997
• Hearing Research
  Sziklai István, He David Z.Z., Dallos Peter, Effect of acetylcholine and GABA on the transfer function of electromotility in isolated outer hair cells
  95:1-2, p. 87 - 99 1996
• Hearing Research
  He David Z.Z., Evans Burt N., Dallos Peter, First appearance and development of electromotility in neonatal gerbil outer hair cells
  78:1, p. 77 - 90 1994

Grants

• Administrative Core/Sponsor: National Institutes of Health/NIH

• SLC7A14 and Syndromic Hearing Loss/Sponsor: Bellucci Foundation/Creighton Biomedical Sciences Department

• Hair Bundle Structure and Dynamics/Sponsor: Oregon Health & Science University

• Mechanisms of Biological Aging of Cochlear Hair Cells/Sponsor: National Institutes of Health/NIH

• Characterization of GJB2 Deficient Mouse Models/Sponsor: Decibel Therapeutics, Inc.

• COBRE: Administrative Core/Sponsor: National Institutes of Health/NIH

• Noise-Induced Hearing Loss Alters Efferent Control of Central Auditory Hyperactivity/Sponsor: National Institutes of Health/NIH

• The Roles of Sin3a in the Auditory and Vestibular Sensory Organs/Sponsor: Childhood Disease Research Endowment

• Physiology and Technology Core/Sponsor: National Institutes of Health/NIH