Gopal Pundlik Jadhav, PhD
Board Membership, Creighton University, Health ans Safety
Assistant Professor
Contact
School of Medicine
Pharmacology and Neuroscience
Translational Hearing
CRISS III 558A
Gopal Pundlik Jadhav, PhD
Board Membership, Creighton University, Health ans Safety
Assistant Professor
After that, Dr. Jadhav worked for about two years as a senior research scientist at GlaxoSmithKline's RD Alternative Discovery & Development (Madrid Trescants, Spain) on a collaborative project that involved structural optimization of the hPDE4 inhibitor GSK675728A to produce novel pharmacophore(s) as potent TbrPDE1 inhibitors that are selective over hPDEs in the management of African sleeping sickness (CNS disorder).
Dr. Gopal started working as a postdoctoral researcher at Creighton University in June 2016 and was later promoted to assistant professor of medicinal chemistry in early 2017. He is presently tenure track faculty in the school of medicine working under Dr. Peter Abel.
Lab Research Focus: Dr. Jadhav’s Lab is aimed at;
A) Molecular docking and Structure Activity Relationship (SAR) based small molecular drug discovery to tackle biological problems such as Neuroinfllamatory disorders, Cancers, Noise induced hearing loss (NIHL) and Antibiotic resistant Bacterial infections. Current projects involve (1) Development of Triggering receptors expressed on myeloid cells-1 (TREM1) inhibitors to treat neuronal disorders, NIHL and liver cancer. (2) Development of small molecules as Mvfr inhibitors to treat antibiotic resistant Pseudomonas aeruginosa infections.
B) PROTAC (Proteolysis targeting chimeras) therapeutics: to address liver cancer and Neuroinflmmations.
C) Dual conjugates of Latanoprost acid to release Nitrous oxide (NO) and Hydrogen suflide (H2S) in the management of gloucoma.
D) Hybrid analogs in the management of Alzheimer’s disease
Curriculum Vitae
Teaching Interests
- Synthetic organic chemistry: Hands on experience in modern synthetic organic chemistry like multi-step syntheses of drug like molecules, heterocycles, peptides, etc., parallel synthesis using Radley’s. Independent planning and execution of SAR.
Research Focus
Drug discovery in Cardiac and cardiovascular disordersDrug discovery in immuno and inflammatory disorders
Drug discovery in Quorum sensing
Drug discovery in Highly neglected diseases
Department
Pharmacology and Neuroscience
Position
Assistant Professor
Book, Chapter/Section
- Laser Therapies : Types, Uses and Safety
Hati Santanu, Jadhav Gopal P., Laser technology to facilitate drug discovery and development processes [Book Chapter] 2020
General
- Jadhav Gopal P., Prathipati Pavan Kumar, Chauhan Harsh, Surface plasmon resonance, Orbitrap mass spectrometry and Raman advancements 2020
Publications
- International journal of molecular sciences
Trivedi Neerja, Bhosale Jitendra D., Pant Amit, Suryawanshi Sonali P., Tiwari Prerna, Abel Peter W., Jadhav Gopal P., Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in Inflammation and Disease: Mechanisms, Therapeutic Potential, and Future Directions
26:21, p. 10386 2025 - International journal of molecular sciences
Boosani Chandra S., Subramanyam Pradeep N., Jadhav Gopal P., Hybrid Receptor-Mediated Molecular Delineations in TNF-α and IGF-1-Induced Costimulatory Effects
26:20, p. 10027 2025 - Current Indian Science
Bhosale Jitendra D., Bendre Ratnamala S., Jadhav Gopal, Dabur Rajesh, An Overview of the Synthesis of 3,4 -Dimethyl- 1H -Pyrrole and its Potential Applications
3 2025 - Molecules (Basel, Switzerland)
Kaur Ishwinder, Jadhav Gopal P., Fischer Peter M., Winkler Gerlof Sebastiaan, The Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease
29:18, p. 4351 2024 - BULLETIN OF THE UNIVERSITY OF KARAGANDA-CHEMISTRY
Bhimanwar R., Thomas A., Kothapalli L., Godase A., Gandhi S., Chandani S., More G., Jadhav G., Choudhary S., Prospective Hybrid Molecules with Dual Anti-Viral and Anti-Thrombotic Activity Against the SARS-CoV-2 Infection and Its Associated Complications Employing in Silico Studies, p. 76 - 88 2022 - FEBS Open Bio
Airhihen Blessing, Jadhav Gopal P., Fischer Peter M., Winkler Gerlof Sebastiaan, Pavanello Lorenzo, 1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg 2+ -dependent binding
9:4, p. 717 - 727 2019 - Journal of Cardiovascular Development and Disease
Kouassi Kouassi T., Gunasekar Palanikumar, Agrawal Devendra K., Jadhav Gopal P., TREM-1; Is it a pivotal target for cardiovascular diseases?
5:3 2018 - Molecules
Bhosale Jitendra D., Dabur Rajesh, Jadhav Gopal P., Bendre R. S., FacIle syntheses and molecular-docking of novel substituted 3,4-dimethyl-1H-pyrrole-2-carboxamide/ carbohydrazide Analogues with antimicrobial and antifungal properties
23:4 2018 - FASEB Journal
Baker Jillian G., Gardiner Sheila M., Woolard Jeanette, Fromont Christophe, Jadhav Gopal P., Mistry Shailesh N., Thompson Kevin S.J., Kellam Barrie, Hill Stephen J., Fischer Peter M., Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease
31:7, p. 3150 - 3166 2017 - Bioorganic and Medicinal Chemistry Letters
Jadhav Gopal P., Kaur Ishwinder, Maryati Maryati, Airhihen Blessing, Fischer Peter M., Winkler G. Sebastiaan, Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1
25:19, p. 4219 - 4224 2015 - Journal of Medicinal Chemistry
Murray Ewan J., Cockayne Alan, Chhabra Siri Ram, Chan Weng C., Williams Paul, Crowley Rebecca C., Truman Alex, Clarke Simon R., Cottam James A., Jadhav Gopal P., Steele Victoria R., O'Shea Paul, Lindholm Catharina, Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors
57:6, p. 2813 - 2819 2014 - Nucleic Acids Research
Maryati Maryati, Kaur Ishwinder, Jadhav Gopal P., Olotu-Umoren Loyin, Oveh Blessing, Hashmi Lubna, Fischer Peter M., Winkler G. Sebastiaan, A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity
42:5, p. e30 2014 - Journal of Medicinal Chemistry
Jadhav Gopal P., Chhabra Siri Ram, Telford Gary, Hooi Doreen S.W., Righetti Karima, Williams Paul, Kellam Barrie, Pritchard David I., Fischer Peter M., Immunosuppressive but non-LasR-inducing analogues of the pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-l-homoserine Lactone
54:9, p. 3348 - 3359 2011 - Indian Drugs
Jadhav Gopal P., Roy Tanya, Deshpande A. D., More H. N., Estimation of proxicam β-cyclodextrine from marketed formulations by RP-HPLC
36:8, p. 506 - 508 1999 - Indian Drugs
Kale A. D., Kachhwaha S. J., Jadhav G. P., Trivedi Piyush, Spectrophotometric estimation of dicyclomine hydrochloride from combined dosage forms by ion pair complex
35:11, p. 718 - 720 1998 - Indian Drugs
Jadhav Gopal P., More H. N., Mahadik K. R., Simultaneous estimation of nalidixic acid and metronidazole using uv/visible spectrophotometer
35:8, p. 475 - 480 1998 - Indian Journal of Pharmaceutical Sciences
Jadhav G. P., More H. N., Mahadik K. R., Simultaneous UV-spectrophotometric estimation of nalidixic acid and metronidazole from various multicomponent formulations
60:4, p. 246 - 248 1998
Presentations
- Invited talk on " The development of selective Beta 1adrenergic receptor inhibitors for the management of Cardiovascular diseases".Venue: SGMSPM's Dnyanvilas College of Pharmacy, Pune, India.https://www.dvcop.com 2018
- Invited talk on "TREM-1 drug discovery, a pivotal target for Cardiovascular disorders"Venue: STES's Sinhgad College of Pharmacy, Pune, India.www.sinhgad.edu 2018