Sudhanva S. Kashyap

Research Focus

Our research is focused on nematode parasitology, studying anthelmintic resistance in tropical parasitic nematode infections of humans. With the effects of climate change, these diseases are closer to the United States than ever before. My lab is particularly interested in filarial nematode infections, like lymphatic filariasis and onchocerciasis. Due to the lack of anthelmintic drugs that kill the adult worm, these diseases can never be ‘cured’. Overuse, misuse, and underdosing of anthelmintic drugs have resulted in several reports of resistance, highlighting the need for new targets, drugs and synergistic drug-interactions.
 
In our lab, we use the free-living nematode C. elegans and the parasitic nematode – Brugia malayi as models to study human filarial infections. We use electrophysiology, pharmacology, and behavioral analysis to characterize nematode ligand gated ion channels as novel anthelmintic drug targets and improve the efficacy of existing anthelmintics.
 
Currently, we are investigating the mode of action of the potassium channel agonist, emodepside and ways to increase its potency. We are also interested in the heterogeneity of large conductance potassium channels in free-living and parasitic nematodes. We are also exploring the role of the nematode nuclear hormone receptor – DAF-12 and macrocyclic lactones like ivermectin, in potentiating the effects of the cholinergic agonist, levamisole. My lab aims to characterize novel anthelmintic drug targets, bridge the gap in knowledge between the in vitro and in vivo pharmacology of these targets and increase the potency of anthelmintics by providing a rational basis for combination therapy.