Brian J. North
Associate Professor
Biomedical Sciences
Contact
School of Medicine
Biomedical Sciences
Graduate School
Biomedical Sciences (Doctorate)
Biomedical Sciences (Master of Science)
Translational Hearing
CRISS II - Criss 2 - 404
Brian J. North
Associate Professor
Biomedical Sciences
Learn more about Dr. North's research.
Cancer Research Focus
The North lab studies the interrelationship between aging and cancer. We are particularly interested in the the role of the ubiquitin-proteasome system in targeting tumor suppressors and oncogenes in an age-dependent manner.
Cancer Research Area(s)
- Colon Cancer
- Skin Cancer
- Age Related Cancer Mechanisms
Research Focus
Molecular basis for aging and its impact on age-related disease susceptibility; Understanding the roles of E3 ubiquitin ligases in tumorigenesis; Regulation and function of NAD+-dependent deacetylasesDepartment
Biomedical Sciences
Position
Associate Professor
General
- Pun Renju, etal Abstract P2037: Bubr1 Is A Critical Regulator Of Cardiac Aging 2023
- Pun Renju, etal Abstract P1068: BubR1 Is A Novel Regulator Of Cardiac Development And Conduction 2022
Publications
- Nature communications
Liu Jing, etal Author Correction: Genetic fusions favor tumorigenesis through degron loss in oncogenes
16:1, p. 7014 2025 - Aging cell
Pun Renju, etal BubR1 Insufficiency Drives Transcriptomic Alterations and Pathology Associated With Cardiac Aging and Heart Failure, p. e70160 2025 - Cancer research (Chicago, Ill.)
Kumari Niti, etal Abstract 4168: NMN supplementation enhances proliferation and aggressiveness in UV-induced skin cancer
85:8_Supplement_1, p. 4168 - 4168 2025 - Journal of the American Heart Association
Pun Renju, etal BubR1 Controls Heart Development by Promoting Expression of Cardiogenesis Regulators, p. e038286 2025 - Frontiers in cell and developmental biology
Pun Renju, etal Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis
12 2025 - Circulation (New York, N.Y.)
Pun Renju, etal Abstract 4144061: BubR1 Insufficiency Recapitulates Changes Associated with Age-Related Cardiac Pathologies
150:Suppl_1 2024 - Seminars in cancer biology
Pun Renju, etal BubR1 and SIRT2: Insights into aneuploidy, aging, and cancer
106-107, p. 201 - 216 2024 - International journal of molecular sciences
Ege Tuba, etal The Role of Molecular and Cellular Aging Pathways on Age-Related Hearing Loss
25:17, p. 9705 2024 - Kim Michael, etal Abstract P1169: BubR1 Regulates Cardiac Development Through CamkII In Vivo 2023
- Cellular oncology (Dordrecht)
Zou Qiang, etal E3 ubiquitin ligases in cancer stem cells: key regulators of cancer hallmarks and novel therapeutic opportunities 2023 - Frontiers in cardiovascular medicine
Pun Renju, etal Role of Connexin 43 phosphorylation on Serine-368 by PKC in cardiac function and disease
9, p. 1080131 - 1080131 2023 - Dai Xiangpeng, etal Editorial 2022
- Cell and Bioscience
Bloom Celia R., etal Physiological relevance of post-translational regulation of the spindle assembly checkpoint protein BubR1
11:1 2021 - Nature Communications
Liu Jing, etal Genetic fusions favor tumorigenesis through degron loss in oncogenes
12:1 2021 - Cell Reports
Shimizu Kouhei, etal Interplay between protein acetylation and ubiquitination controls MCL1 protein stability
37:6 2021 - Molecular biology reports
Ma Ying, etal Regulation of topoisomerase II stability and activity by ubiquitination and SUMOylation
48:9, p. 6589 - 6601 2021 - Mediators of Inflammation
Kumari Niti, etal Unraveling the Molecular Nexus between GPCRs, ERS, and EMT
2021 2021 - Nature Cell Biology
Gao Yang, etal Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy
22:9, p. 1064 - 1075 2020 - Biochimica et Biophysica Acta - Reviews on Cancer
Cheng Ji, etal Functional analysis of deubiquitylating enzymes in tumorigenesis and development
1872:2 2019 - Molecular Oncology
Ma Ying, etal SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation
13:2, p. 307 - 321 2019 - Biochimica et Biophysica Acta - Reviews on Cancer
Cheng Ji, etal The emerging role for Cullin 4 family of E3 ligases in tumorigenesis
1871:1, p. 138 - 159 2019 - Protein and Cell
Ci Yanpeng, etal SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation
9:10, p. 879 - 889 2018 - Aging Cell
Cheng Ji, etal The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease
17:5 2018 - Biochimica et Biophysica Acta - Reviews on Cancer
Cheng Ji, etal Functional analysis of Cullin 3 E3 ligases in tumorigenesis
1869:1, p. 11 - 28 2018 - Biochimica et Biophysica Acta - Reviews on Cancer
Guo Jianping, etal Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology
1868:2, p. 341 - 358 2017 - Nature
Wang Bin, etal TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
545:7654, p. 365 - 369 2017 - PloS one
North Brian J., etal Enhancement of pomalidomide anti-Tumor response with ACY-241, a selective HDAC6 inhibitor
12:3 2017 - Science Signaling
Nihira Naoe T., etal Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function
10:466 2017 - Science Signaling
Shimizu Kouhei, etal The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis
10:460 2017 - Oncotarget
Tan Yuyong, etal Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6
8:29, p. 47890 - 47901 2017 - Oncotarget
Li Xiaoning, etal Smurf1 regulation of DAB2IP controls cell proliferation and migration
7:18, p. 26057 - 26069 2016 - Nature Communications
Rumpf Tobias, etal Selective Sirt2 inhibition by ligand-induced rearrangement of the active site
6 2015 - EMBO Journal
North Brian J., etal SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
33:13, p. 1438 - 1453 2014 - Oncotarget
Wu Xiaomian, etal SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination
5:12, p. 4211 - 4221 2014 - Oncotarget
Dai Xiangping, etal Negative regulation of DAB2IP by Akt and SCFFbw7 pathways
5:10, p. 3307 - 3315 2014 - Neoplasia
Bonezzi Katiuscia, etal Inhibition of SIRT2 potentiates the anti-motility activity of taxanes
14:9, p. 846 - 854 2012 - Cell Metabolism
Price Nathan L., etal SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
15:5, p. 675 - 690 2012 - Circulation Research
North Brian J., etal The intersection between aging and cardiovascular disease
110:8, p. 1097 - 1108 2012 - Proceedings of the National Academy of Sciences of the United States of America
Beirowski Bogdan, etal Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling
108:43, p. E952 - E961 2011 - Journal of Biological Chemistry
Ahuja Nidhi, etal Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase
282:46, p. 33583 - 33592 2007 - PloS one
North Brian J., etal Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis
2:8 2007 - Journal of Biological Chemistry
North Brian J., etal Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation
282:27, p. 19546 - 19555 2007 - Trends in Biochemical Sciences
North Brian J., etal Sirtuins
32:1, p. 1 - 4 2007 - Methods
North Brian J., etal Preparation of enzymatically active recombinant class III protein deacetylases
36:4, p. 338 - 345 2005 - FASEB Journal
Waltregny David, etal Histone deacetylase HDAC8 associates with smooth muscle α-actin and is essential for smooth muscle cell contractility
19:8, p. 966 - 968 2005 - PLoS Biology
Pagans Sara, etal SIRT1 regulates HIV transcription via Tat deacetylation
3:2, p. 210 - 220 2005 - American Journal of Pathology
Waltregny David, etal Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues
165:2, p. 553 - 564 2004 - European Journal of Histochemistry
Waltregny D., etal Screening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class I HDAC profiles between epithelial and stromal cells
48:3, p. 273 - 290 2004 - Genome Biology
North Brian J., etal Sirtuins
5:5 2004 - Molecular Cell
North Brian J., etal The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
11:2, p. 437 - 444 2003 - Methods in Enzymology
Verdin Eric, etal Measurement of Mammalian Histone Deacetylase Activity
377, p. 180 - 196 2003 - Journal of Cell Biology
Schwer Björn, etal The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
158:4, p. 647 - 657 2002 - Developmental Biology
Verzi Michael P., etal N-twist, an evolutionarily conserved bHLH protein expressed in the developing CNS, functions as a transcriptional inhibitor
249:1, p. 174 - 190 2002
Awards
- National Institutes of Health K01 Career Development Award
National Institutes of Health K01 Career Development Award (NIH/NIA AG052627) - Gustavus Adolphus College Decade Award
Gustavus Adolphus College Decade Award - BIDMC/National Institutes of Aging T32 Translational Research in Aging Award
BIDMC/National Institutes of Aging T32 Translational Research in Aging Award