Peter Stephen Steyger, PhD

Department

Biomedical Sciences

Position

Professor

Book, Chapter/Section

• Neurotology Updates
  Eğilmez Oğuz Kadir, Aksoy Fadlullah, Kalcioglu Mahmut Tayyar, Steyger Peter S., Ototoxicity: Cochleotoxicity and Vestibulotoxicity [Book Chapter] 2024
• Inflammatory Mechanisms in Mediating Hearing Loss
  Steyger Peter S., Inflammation potentiates cochlear uptake of ototoxins and drug-induced hearing loss [Book Chapter] 2018

Books

• Steyger Peter S, Mechanisms of aminoglycoside ototoxicity and strategies for prevention 2005

General

• Steyger Peter S., Watts Kelly L., Cunningham Lisa L., Esquivel Carlos R., Zuo Jian, Editorial 2018
• Adler Henry J., Tang Stephen J., Tejani Viral D., Wong Victor, Gluck Sarah D., Anbuhl Kelsey L., Atcherson Samuel R., Huyck Julia J., Goldsworthy Ray L., Heng Joseph, Hight Ariel Edward, Jacobson Barry D., Karasawa Takatoshi, Malone Alexander K., Barlow Nathan, Brennan Marc A., Brigande John V., Kovačić Damir, Lim Stacey R., Nolan Lisa S., Pisano Dominic V., Rao Valluri R.M., Raphael Robert M., Ratnanather J. Tilak, Sinan Moaz, Reiss Lina A.J., Ruffin Chad V., Schwalje Adam T., Stahn Patricia, Steyger Peter S., Buran Brad N., Fraenzer Juergen Theodor, Gale Jonathan E., Gallun Frederick J., Community network for deaf scientists 2017
• Steyger Peter S., Volta Review 2005
• Adler H. J., Liebman J., Raphael R. M., Ratnanather J. T., Steyger P. S., Early education of the deaf [10] 1998

Articles

• Steyger Peter, From Screen to Trial 2018

Publications

• Journal of pharmaceutical and biomedical analysis
  Dash Shreshtha, Smith D. David, Steyger Peter S., McDevitt Molly T., Determination of Gentamicin C-subtypes in Inner Ear Perilymph Using Liquid Chromatography with Fluorescence Detection
  273, p. 117394 2026
• Pharmaceuticals
  Dash Shreshtha, Zuo Jian, Steyger Peter S., Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials
  15:9 2022
• Otolaryngologic Clinics of North America
  Steyger Peter S., Mechanisms of Ototoxicity and Otoprotection
  54:6, p. 1101 - 1115 2021
• Journal of Neuroinflammation
  Mathy Nicholas W., Burleigh Olivia, Kochvar Andrew, Whiteford Erin R., Behrens Matthew, Marta Patrick, Tian Cong, Gong Ai Yu, Drescher Kristen M., Steyger Peter S., Chen Xian Ming, Shibata Annemarie, A novel long intergenic non-coding RNA, Nostrill, regulates iNOS gene transcription and neurotoxicity in microglia
  18:1 2021
• Journal of cystic fibrosis
  Garinis A., Steyger P., McPhail G., Poling G., Brewer C., Petersen L., Konrad-Martin D., Rubenstein R., Hunter L., 105: Ototoxicity management for patients with cystic fibrosis
  20, p. S53 2021
• Frontiers in Education
  Huyck Julia Jones, Kumar Santosh, Jawadi Zina, Kovacic Damir, Kumar Rachit, Lim Stacey R., Mo Chengeng, Rao Valluri R., Nolan Lisa S., Parbery-Clark Alexandra, Pisano Dominic V., Raphael Robert M., Watkins Greg D., Tejani Viral D., Tran Emma D., Valli Mikaeel, Wayne Rachel V., Wheeler Lindsey R., White Stephanie L., Wong Victor, Ratnanather J. Tilak, Steyger Peter S., Yuk M. Caroline, Reiss Lina A.J., Spencer Nathaniel J., Tang Stephen J., Adler Henry J., Anbuhl Kelsey L., Buran Brad N., Eddolls Morgan, Atcherson Samuel R., Cakmak Ozan, Dwyer Robert T., El May Fadhel, Fraenzer Juergen Theodor, Gallun Frederick J., Hight Ariel Edward, Funkhouser Rebekah, Gagliardini Mathilde, Goldsworthy Raymond L., Gouin Samir, Heng Joseph, Supporting Equity and Inclusion of Deaf and Hard-of-Hearing Individuals in Professional Organizations
  6 2021
• American Journal of Audiology
  Steyger Peter S., Mechanisms of aminoglycoside-and cisplatin-induced ototoxicity
  30:3S, p. 887 - 900 2021
• Hearing Research
  Tian Cong, Voss Robert, Johnson Kenneth R., Lett Jaclynn M., Ohlemiller Kevin K., Salt Alec N., Hartsock Jared J., Steyger Peter S., CACHD1-deficient mice exhibit hearing and balance deficits associated with a disruption of calcium homeostasis in the inner ear
  409 2021
• Frontiers in Neurology
  Coffin Allison B., Boney Robert, Hill Jordan, Tian Cong, Steyger Peter S., Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings
  12 2021
• Frontiers in Neuroscience
  Prayuenyong Pattarawadee, Steyger Peter S., Kros Corné J., Baguley David M., Preferential Cochleotoxicity of Cisplatin
  15 2021
• Cold Spring Harbor Perspectives in Medicine
  Kros Corné J., Steyger Peter S., Aminoglycoside- and cisplatin-induced ototoxicity
  9:11 2019
• Science Advances
  Jiang Meiyan, Johnson Anastasiya, Kachelmeier Allan, Steyger Peter S., Li Hongzhe, Karasawa Takatoshi, Taghizadeh Farshid, Zhang Yuan, Meier William B., Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss
  5:7 2019
• Hearing Journal
  Steyger Peter S., Garinis Angela C., Genetic Contributions to Age-Related Hearing Loss
  72:5, p. 10 - 13 2019
• Science Translational Medicine
  Nyberg Sophie, Shi Xiaorui, Steyger Peter S., Dabdoub Alain, Joan Abbott N., Delivery of therapeutics to the inner ear
  11:482 2019
• PloS one
  Kachelmeier Allan, Steyger Peter S., Jiang Meiyan, Shola Tsering, Meier William B., Johnson Anastasiya, Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells
  13:11 2018
• International Journal of Audiology
  Garinis Angela C., Kemph Alison, Tharpe Anne Marie, Weitkamp Joern Hendrik, McEvoy Cynthia, Steyger Peter S., Monitoring neonates for ototoxicity
  57:sup4, p. S41 - S48 2018
• Frontiers in Cellular Neuroscience
  Jiang Meiyan, Steyger Peter S., Karasawa Takatoshi, Aminoglycoside-induced cochleotoxicity
  11 2017
• International Journal of Pediatric Otorhinolaryngology
  Garinis Angela C., Liao Selena, Cross Campbell P., Galati Johnathan, Ettinger Olivia, McEvoy Lindsey, Moneta Lauren, Lubianski Troy, Coopersmith Noe, Vigo Nicholas, Hart Christopher, Riddle Artur, Nold Casey, Durham Heather, MacArthur Carol, McEvoy Cynthia, Steyger Peter S., Mace Jess C., Middaugh Jessica L., Wood Anna Marie, Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit
  97, p. 42 - 50 2017
• Hearing Journal
  Steyger Peter S., Is Auditory Synaptopathy a Result of Drug-Induced Hearing Loss?
  70:4, p. 8 - 9 2017
• Dyes and Pigments
  Chu Yu Hsuan, Escobedo Jorge O., Jiang Meiyan, Steyger Peter S., Strongin Robert M., Rhodamine analogs for molecular ruler applications
  126, p. 46 - 53 2016
• Toxicology Letters
  Karasawa Takatoshi, Steyger Peter S., An integrated view of cisplatin-induced nephrotoxicity and ototoxicity
  237:3, p. 219 - 227 2015
• Expert Opinion on Therapeutic Patents
  Jiang Meiyan, Steyger Peter S., An evaluation of US patent 2015065565 (A1) for a new class of SGLT2 inhibitors for treatment 1 of type II diabetes mellitus
  25:11, p. 1349 - 1352 2015
• Science Translational Medicine
  Koo Ja Won, Quintanilla-Dieck Lourdes, Jiang Meiyan, Liu Jianping, Urdang Zachary D., Steyger Peter S., Allensworth Jordan J., Cross Campbell P., Li Hongzhe, Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity
  7:298 2015
• Hearing Journal
  Steyger Peter S., Novel Aminoglycoside Antibiotics Show Reduced Ototoxicity Risk
  68:4, p. 32 - 35 2015
• Hearing Journal
  Steyger Peter S., Garinis Angela C., Hearing Loss Risk Factors for Cystic Fibrosis Patients
  69:4, p. 8 - 9 2015
• PloS one
  Yang Yuqin, Jiang Zhi Gen, Chen Fangyi, Karasawa Takatoshi, Ma Ke Tao, Guan Bing Cai, Shi Xiao Rui, Li Hongzhe, Steyger Peter S., Nuttall Alfred L., Diverse Kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles
  10:5 2015
• Frontiers in Cellular Neuroscience
  Li Hongzhe, Steyger Peter S., Kachelmeier Allan, Furness David N., Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells
  9:APR 2015
• PloS one
  Liu Jianping, Li Hongzhe, Steyger Peter S., Dai Chunfu, Kachelmeier Allan, Uptake of fluorescent gentamicin by peripheral vestibular cells after systemic administration
  10:3 2015
• International Journal of Pediatric Otorhinolaryngology
  Cross Campbell P., Srikanth Priya, Liao Selena, Urdang Zachary D., Garinis Angela C., Steyger Peter S., Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure
  79:11, p. 1915 - 1919 2015
• Otolaryngology-head and neck surgery
  Luk Lauren J., Steyger Peter, Li Hongzhe, Perilymphatic Gentamicin Trafficking through Basolateral Channels May Underlie Enhanced Ototoxicity by Noise-Induced Threshold Shifts
  151:1_suppl, p. P222 - P222 2014
• Otolaryngology-head and neck surgery
  Liao Selena, Lubianski Troy, Steyger Peter, Martin William H., Mace Jess, MacArthur Carol, Differences in DPOAE and AABR in Noise-Exposed Infants in the Neonatal Intensive Care Unit
  149:2_suppl, p. P244 - P244 2013
• Otolaryngology-head and neck surgery
  Liao Selena, Mace Jess, MacArthur Carol, Martin William H., Lubianski Troy, Steyger Peter, Noise Exposure in the Neonatal Intensive Care Unit: A Prospective Study
  149:2_suppl, p. P249 - P249 2013
• Otolaryngology - Head and Neck Surgery
  Quintanilla-Dieck Lourdes, Larrain Barbara, Trune Dennis, Steyger Peter S., Effect of systemic lipopolysaccharide-induced inflammation on cytokine levels in the murine cochlea
  149:2, p. 301 - 303 2013
• PloS one
  Karasawa Takatoshi, Sibrian-Vazquez Martha, Strongin Robert M., Steyger Peter S., Identification of Cisplatin-Binding Proteins Using Agarose Conjugates of Platinum Compounds
  8:6 2013
• Hearing Research
  Zhang Ru, Steyger Peter S., Zhang Yi Bo, Dai Chun Fu, Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs
  298, p. 49 - 59 2013
• Cell Biochemistry and Biophysics
  Wang Tian, Yang Yu qin, Karasawa Takatoshi, Ma Ke Tao, Jiang Meiyan, Jiang Zhi Gen, Wang Qi, Phillips Amanda, Guan Bing Cai, Xie Ding Hua, Steyger Peter S., Bumetanide Hyperpolarizes Madin-Darby Canine Kidney Cells and Enhances Cellular Gentamicin Uptake by Elevating Cytosolic Ca2+ Thus Facilitating Intermediate Conductance Ca2+-Activated Potassium Channels
  65:3, p. 381 - 398 2013
• Hearing Journal
  Steyger Peter S., Ototoxic antibiotics
  66:4, p. 24 - 26 2013
• PloS one
  Uribe Phillip M., Asuncion James D., Sun Huifang, Wang Kevin, Wang Qi, Chen Chien Wei, Steyger Peter S., Smith Michael E., Matsui Jonathan I., Aminoglycoside-Induced Hair Cell Death of Inner Ear Organs Causes Functional Deficits in Adult Zebrafish (Danio rerio)
  8:3 2013
• PloS one
  Uribe Phillip M., Sibrian-Vazquez Martha, Mueller Melissa A., Gleichman Julia S., Kramer Matthew D., Wang Qi, Strongin Robert M., Steyger Peter S., Cotanche Douglas A., Matsui Jonathan I., Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio)
  8:2 2013
• Audiology and Neuro-Otology
  Zhai Feng, Zhang Ru, Zhang Ting, Steyger Peter S., Dai Chun Fu, Preclinical and clinical studies of unrelieved aural fullness following intratympanic gentamicin injection in patients with intractable Ménière's disease
  18:5, p. 297 - 306 2013
• Otolaryngology-head and neck surgery
  Quintanilla-Dieck Lourdes, Larrain Barbara, Trune Dennis R., Steyger Peter, Cytokines Induced by Gentamicin and Sepsis in the Cochlea
  147:2_suppl, p. P84 - P84 2012
• Journal of Clinical Oncology
  Brock Penelope R., Neuwelt Edward A., Blakley Brian W., Freyer David R., Campbell Kathleen C.M., Steyger Peter S., Rassekh Shahrad R., Chang Kay W., Knight Kristin R., Sullivan Michael, Fligor Brian J., Rajput Kaukab, Platinum-induced ototoxicity in children
  30:19, p. 2408 - 2417 2012
• Hearing Journal
  Steyger Peter S., Journal club
  65:4, p. 18 - 20 2012
• Natural Product Communications
  Escobedo Jorge O., Wang Qi, Steyger Peter S., Strongin Robert M., Chu Yu Hsuan, Live cell imaging of a fluorescent gentamicin conjugate
  7:3, p. 317 - 320 2012
• Hearing Research
  Zhang Yi Bo, Steyger Peter S., Dai Chun Fu, Zhang Wei Feng, Zhang Ru, Uptake of gentamicin by vestibular efferent neurons and superior olivary complex after transtympanic administration in guinea pigs
  283:1-2, p. 169 - 179 2012
• JARO - Journal of the Association for Research in Otolaryngology
  Stepanyan Ruben S., Indzhykulian Artur A., Catalinavélez-Ortega A., Boger Erich T., Steyger Peter S., Friedman Thomas B., Frolenkov Gregory I., TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells
  12:6, p. 729 - 740 2011
• Toxicological Sciences
  Karasawa Takatoshi, Wang Qi, David Larry L., Steyger Peter S., Calreticulin binds to gentamicin and reduces drug-induced ototoxicity
  124:2, p. 378 - 387 2011
• Audiology and Neuro-Otology
  Koo Ja Won, Wang Qi, Steyger Peter S., Infection-mediated vasoactive peptides modulate cochlear uptake of fluorescent gentamicin
  16:6, p. 347 - 358 2011
• Integrative Biology
  Karasawa Takatoshi, Steyger Peter S., Intracellular mechanisms of aminoglycoside-induced cytotoxicity
  3:9, p. 879 - 886 2011
• Seminars in hearing
  Steyger Peter S., Mechanisms Involved in Ototoxicity
  32:3, p. 217 - 228 2011
• PloS one
  Li Hongzhe, Wang Qi, Steyger Peter S., Acoustic trauma increases cochlear and hair cell uptake of gentamicin
  6:4 2011
• Scientific Reports
  Li Hongzhe, Steyger Peter S., Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
  1 2011
• PloS one
  Alharazneh Abdelrahman, Monfared Ashkan, Luk Lauren, Huth Markus, Steyger Peter S., Cheng Alan G., Ricci Anthony J., Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity
  6:7 2011
• Laryngoscope
  Zhang Yiliang, Steyger Peter S., Zhang Ru, Dai Chunfu, Yongfu Yu Y., Comparison of gentamicin distribution in the inner ear following administration via the endolymphatic sac or round window
  120:10, p. 2054 - 2060 2010
• Hearing Research
  Wang Qi, Steyger P. S., Kachelmeier Allan, Competitive antagonism of fluorescent gentamicin uptake in the cochlea
  268:1-2, p. 250 - 259 2010
• Otology and Neurotology
  Zhai Feng, Liu Jian Ping, Dai Chun Fu, Wang Qi, Steyger Peter S., Evidence-Based modification of intratympanic gentamicin injections in patients with intractable vertigo
  31:4, p. 642 - 648 2010
• The FASEB journal
  Wang Tian, Steyger Peter, Jiang Zhi‐Gen, Yang Yu‐Qin, Wang Qi, Ma Ke‐Tao, Ionic mechanisms for bumetanide enhancement on aminoglycoside ototoxicity: a study with MDCK cells
  24:S1, p. lb486 - lb486 2010
• Brain Research
  Tiede LeAnn, Steyger Peter S., Nichols Michael G., Hallworth Richard J., Metabolic imaging of the organ of corti — A window on cochlea bioenergetics
  1277, p. 37 - 41 2009
• JARO - Journal of the Association for Research in Otolaryngology
  Wang Qi, Steyger Peter S., Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells
  10:2, p. 205 - 219 2009
• The FASEB journal
  Ma Ke‐tao, Wang Qi, Steyger Peter S, Jiang Zhi‐Gen, Yang Yu‐Qin, Possible gentamicin trafficking channels in guinea pig cochlear stria vascularis cells
  23:S1 2009
• Noise and Health
  Li Hongzhe, Steyger Peter, Synergistic ototoxicity due to noise exposure and aminoglycoside antibiotics
  11:42, p. 26 - 32 2009
• Perspectives on hearing and hearing disorders. Research and diagnostics
  Steyger Peter S., Synergistic Ototoxicity of Noise and Chemical Ototoxins
  12:2, p. 48 2008
• Hearing Research
  Dai Chun Fu, Steyger Peter S., A systemic gentamicin pathway across the stria vascularis
  235:1-2, p. 114 - 124 2008
• Hearing Research
  Dai C. F., Mangiardi D., Cotanche D. A., Steyger P. S., Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo
  213:1-2, p. 64 - 78 2006
• Volta Review
  Steyger Peter S., Cellular uptake of aminoglycosides
  105:3, p. 299 - 324 2005
• Hearing Research
  Myrdal Sigrid E., Steyger Peter S., TRPV1 regulators mediate gentamicin penetration of cultured kidney cells
  204:1-2, p. 170 - 182 2005
• Hearing Research
  Myrdal Sigrid E., Johnson Katherine C., Steyger Peter S., Cytoplasmic and intra-nuclear binding of gentamicin does not require endocytosis
  204:1-2, p. 156 - 169 2005
• Neuroscience
  Vass Z., Trune D. R., Dai C. F., Steyger P. S., Jancsó G., Nuttall A. L., Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries
  124:4, p. 919 - 927 2004
• Hearing Research
  Dai C. F., Vass Z., Nuttall A. L., Wang Z. M., Steyger P. S., Expression of Trk A receptors in the mammalian inner ear
  187:1-2, p. 1 - 11 2004
• JARO - Journal of the Association for Research in Otolaryngology
  Steyger P. S., Dai C. F., Peters S. L., Rehling J., Hordichok A., Uptake of Gentamicin by Bullfrog Saccular Hair Cells in vitro
  4:4, p. 565 - 578 2003
• Journal of Neurophysiology
  Zheng Jiefu, Dai Chunfu, Steyger Peter S., Nuttall Alfred L., Kim Youngki, Vass Zoltan, Ren Tianying, Vanilloid receptors in hearing
  90:1, p. 444 - 455 2003
• Journal of Neurocytology
  Jensen-Smith H. C., Eley J., Steyger P. S., Luduena R. F., Hallworth Richard J., Jensen Smith Heather C., Cell type-specific reduction of β tubulin isotypes synthesized in the developing gerbil organ of Corti
  32:2, p. 185 - 197 2003
• Journal of Neurocytology
  Jensen-Smith Heather C., Steyger Peter S., Ludueña Richard F., Hallworth Richard J., Eley Jonquille, Cell type-specific reduction of β tubulin isotypes synthesized in the developing gerbil organ of Corti
  32:2, p. 185 - 197 2003
• Neuroscience
  Vass Z., Nuttall A. L., Steyger P. S., Hordichok A. J., Trune D. R., Jancsó G., Capsaicin stimulation of the cochlea and electric stimulation of the trigeminal ganglion mediate vascular permeability in cochlear and vertebro-basilar arteries
  103:1, p. 189 - 201 2001
• Hearing Research
  Qiu Jian Hua, Steyger Peter S., Trune Dennis R., Nuttall Alfred L., Co-existence of tyrosine hydroxylase and calcitonin gene-related peptide in cochlear spiral modiolar artery of guinea pigs
  155:1-2, p. 152 - 160 2001
• Journal of Biological Chemistry
  Silberbach Michael, Stork Philip J.S., Steyger Peter S., Roberts Charles T., Hershberger Ray E., Gorenc Travis, Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes
  274:35, p. 24858 - 24864 1999
• ImmunoMethods
  Steyger Peter, Assessing confocal microscopy systems for purchase
  18:4, p. 435 - 446 1999
• Journal of Neuroscience
  Steyger Peter S., Baird Richard A., Gillespie Peter G., Myosin Iβ is located at tip link anchors in vestibular hair bundles
  18:12, p. 4603 - 4615 1998
• Journal of Controlled Release
  Steyger P. S., Ulbrich K., Baban D. F., Brereton M., Seymour L. W., Intratumoural
  39:1, p. 35 - 46 1996
• Hearing Research
  Hallworth Richard J., Wiederhold Michael L., Campbell John B., Steyger Peter S., Atomic force microscope observations of otoconia in the newt
  85:1-2, p. 115 - 121 1995
• Hearing Research
  Steyger Peter S., Wiederhold Michael L., Batten Jeffrey, The morphogenic features of otoconia during larval development of Cynops pyrrhogaster, the Japanese red-bellied newt
  84:1-2, p. 61 - 71 1995
• Journal of Electron Microscopy Technique
  Furness David N., Hackney Carole M., Steyger Peter S., Organization of microtubules in cochlear hair cells
  15:3, p. 261 - 279 1990
• Hearing Research
  Steyger P. S., Furness D. N., Hackney C. M., Richardson G. P., Tubulin and microtubules in cochlear hair cells
  42:1, p. 1 - 16 1989
• British Journal of Audiology
  Steyger P. S., Furness D. N., Hackney C. M., Richardson G. P., Immunocytochemistry of cytoskeletal proteins in the guinea pig cochleaa comparison of staining patterns with different commercially available antibodies and ultrastructure
  23:2, p. 143 - 174 1989