Juliane K . Strauss-Soukup, BS, PhD

Department

Chemistry and Biochemistry

Position

Professor

Books

• Ribozymes
  Soukup Juliane, The glmS Ribozyme and Its Multifunctional Coenzyme Glucosamine‐6‐phosphate [Book Chapter] 2021
• Progress in Molecular Biology and Translational Science
  Soukup Juliane K., Chapter Five - The Structural and Functional Uniqueness of the glmS Ribozyme [Book Chapter] 2014
• Progress in Molecular Biology and Translational Science
  Soukup Juliane K., The Structural and Functional Uniqueness of the glmS Ribozyme [Book Chapter] 2013
• Catalytic RNA
  Soukup Juliane K., The structural and functional uniqueness of the glmS ribozyme [Book Chapter] 2013
• RNA
  Strauss-Soukup Juliane K., etal 11 - Ribozyme Enzymology [Book Chapter] 2001

Articles

• McCarthy Tom J., etal Ligand Requirements for glmS Ribozyme Self-Cleavage (DOI:10.1016/j.chembiol.2005.09.006) 2006

Publications

• Infection and immunity
  Graham Marion L., etal Long non-coding RNA U90926 modulates IFN-γ-stimulated gene transcription and cell-intrinsic anti-Cryptosporidium defense in intestinal epithelial cells, p. e0032825 2025
• mBio
  Jin Kehua, etal Targeting the interaction between long noncoding RNA XR_001779380 and Prdm1 to enhance IFN-γ immunity in murine neonatal intestinal epithelial cells, p. e0077325 2025
• Nature communications
  Deng Silu, etal Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses
  14:1, p. 1456 - 17 2023
• mBio
  Gong Ai Yu, etal LncRNA XR_001779380 Primes Epithelial Cells for IFN-g-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense
  12:5 2021
• PLoS pathogens
  Li Juan, etal A host cell long noncoding RNA NR_033736 regulates type I interferon-mediated gene transcription and modulates intestinal epithelial anti-Cryptosporidium defense
  17:1 2021
• Journal of Immunology
  Li Min, etal Induction of a long noncoding rn A Transcript, NR-045064, promotes defense gene transcription and facilitates intestinal epithelial cell responses against cryptosporidium infection
  201:12, p. 3630 - 3640 2018
• Journal of Infectious Diseases
  Ming Zhenping, etal Attenuation of intestinal epithelial cell migration during cryptosporidium parvum infection involves parasite Cdg7-FLc-1030 RNA-Mediated induction and release of dickkopf-1
  218:8, p. 1336 - 1347 2018
• International Journal for Parasitology
  Ming Zhenping, etal Trans-suppression of host CDH3 and LOXL4 genes during Cryptosporidium parvum infection involves nuclear delivery of parasite Cdg7_FLc_1000 RNA
  48:6, p. 423 - 431 2018
• Biophysical journal
  Klem Heidi, etal Kinetic Investigation of Natural Products and Extracts for Potential Riboswitch Ligands
  114:3, p. 434a - 434a 2018
• Biophysical journal
  Strauss-Soukup Juliane, etal Ornithine Decarboxylase Antizyme Pseudoknot RNA Binding to Spermine Regulates Gene Expression
  114:3, p. 438a - 438a 2018
• Biophysical journal
  Stoupa Samantha M., etal Identification of an Allosteric Twister Ribozyme for Use as a Synthetic Genetic Switch
  114:3, p. 433 - 433a 2018
• Journal of Infectious Diseases
  Ming Zhenping, etal Involvement of cryptosporidium parvum Cdg7-FLc-1000 RNA in the attenuation of intestinal epithelial cell migration via trans-suppression of host cell SMPD3
  217:1, p. 122 - 133 2018
• Cellular Microbiology
  Wang Yang, etal Delivery of parasite Cdg7_Flc_0990 RNA transcript into intestinal epithelial cells during Cryptosporidium parvum infection suppresses host cell gene transcription through epigenetic mechanisms
  19:11 2017
• The Journal of Infectious Diseases
  Wang Yang, etal Delivery of Parasite RNA Transcripts into Infected Epithelial Cells during Cryptosporidium Infection and its Potential Impact on Host Gene Transcription
  215:4, p. 636 - 643 2017
• The Journal of Infectious Diseases
  Wang Y., etal Delivery of Parasite RNA Transcripts into Infected Epithelial Cells during Cryptosporidium Infection and its Potential Impact on Host Gene Transcription 2016
• Journal of Immunology
  Hu Guoku, etal LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling
  196:6, p. 2799 - 2808 2016
• ACS Chemical Biology
  Fei X., etal Phosphatase-inert glucosamine 6-phosphate mimics serve as actuators of the glmS riboswitch
  9:12, p. 2875 - 2882 2014
• Nebraska Academy of Sciences, PO Box 880410 Lincoln NE 68588-0410 United States. [np]. Apr 2012
  Holmes Zachariah, etal EFFECT OF MICRORNA-183 FAMILY ON EXPRESSION OF GENES THAT REINFORCE NEUROSENSORY CELL FATE IN THE INNER EAR 2012
• Nebraska Academy of Sciences, PO Box 880410 Lincoln NE 68588-0410 United States. [np]. Jun 2011
  Kavan Andrew, etal EVOLUTIONARY CONSERVATION OF A POTENTIAL MAMMALIAN RIBOSWITCH 2011
• Biophysical Journal
  Soukup Julie, etal Structure and mechanism of the glmS ribozyme
  98:3, p. 262a - 262a 2010
• Nature Structural and Molecular Biology
  Jansen Joshua A., etal Backbone and nucleobase contacts to glucosamine-6-phosphate in the glmS ribozyme
  13:6, p. 517 - 523 2006
• Chemistry and Biology
  McCarthy Tom J., etal Ligand requirements for glmS ribozyme self-cleavage
  12:11, p. 1221 - 1226 2005
• Chemistry & Biology
  McCarthy Tom J., etal Ligand requirements for glmS ribozyme self-cleavage
  12:11, p. 1221 - 1226 2005
• Current Opinion in Structural Biology
  Soukup Juliane K., etal Riboswitches exert genetic control through metabolite-induced conformational change
  14:3, p. 344 - 349 2004
• Biochemistry
  Soukup Juliane K., etal Identification of A-minor tertiary interactions within a bacterial group I intron active site by 3-deazaadenosine interference mapping
  41:33, p. 10426 - 10438 2002
• Nature Structural Biology
  Schmeing T. Martin, etal A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits
  9:3, p. 225 - 230 2002
• Journal of Molecular Biology
  Strauss-Soukup Juliane K., etal A chemical phylogeny of group I introns based upon interference mapping of a bacterial ribozyme
  302:2, p. 339 - 358 2000
• Nature Structural Biology
  Basu Soumitra, etal A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor
  5:11, p. 986 - 992 1998
• Biophysical Chemistry
  Strauss-Soukup Juliane K., etal Effect of base composition on DNA bending by phosphate neutralization
  72:3, p. 297 - 306 1998
• Nucleic Acids Research
  Tomky Laura A., etal Effects of phosphate neutralization on the shape of the AP-1 transcription factor binding site in duplex DNA
  26:10, p. 2298 - 2305 1998
• Biochemistry
  Strauss-Soukup Juliane K., etal Electrostatic effects in DNA bending by GCN4 mutants
  37:4, p. 1060 - 1066 1998
• Journal of Biological Chemistry
  Strauss-Soukup Juliane K., etal Role of asymmetric phosphate neutralization in DNA bending by PU.1
  272:50, p. 31570 - 31575 1997
• Biochemistry
  Strauss-Soukup J. K., etal DNA bending by GCN4 mutants bearing cationic residues
  36:33, p. 10026 - 10032 1997
• Biochemistry
  Strauss-Soukup J. K., etal Effects of neutralization pattern and stereochemistry on DNA bending by methylphosphonate substitutions
  36:29, p. 8692 - 8698 1997
• Proceedings of the National Academy of Sciences of the United States of America
  Strauss J. K., etal DNA bending by hexamethylene-tethered ammonium ions
  93:18, p. 9515 - 9520 1996
• Chemistry and Biology
  Strauss Juliane K., etal DNA bending by a phantom protein
  3:8, p. 671 - 678 1996
• Science
  Strauss Juliane K., etal DNA bending by asymmetric phosphate neutralization
  266:5192, p. 1829 - 1834 1994

Grants

• Creighton University Cancer and Smoking Disease Research Program/Sponsor: State of Nebraska - LB595

• Development Program/Sponsor: State of Nebraska - LB595

• Administration & Planning Program/Sponsor: State of Nebraska - LB595

• Development Program/Sponsor: State of Nebraska - LB595

• Research Personnel Salary Support/Sponsor: State of Nebraska - LB692

• Research Personnel Salary Support/Sponsor: State of Nebraska - LB692

• Control of Gene Expression by a Putative Eukaryotic Polyamine Riboswitch/Sponsor: CURAS Faculty Research Fund

• BioTek LogPhase 600 Microbiology Reader/Sponsor: State of Nebraska - LB692

• Cancer and Smoking Disease Research Program/Sponsor: State of Nebraska - LB595

• LB692 New Initiatives Grant Reviewers/Sponsor: State of Nebraska - LB692

• Elsevier Pure Master Software Subscription Renewal/Sponsor: State of Nebraska - LB692

• Laboratory Freezer/Sponsor: State of Nebraska - LB692

• National Institute of Antimicrobial Resistance Research and Education Institutional Membership/Sponsor: State of Nebraska - LB692

• Write Winning Grant Proposal Seminar 2022/Sponsor: State of Nebraska - LB692

• Bridge Funding for NIH project: Examination of Ornithine Decarboxylase Antizyme RNA Structure and Function for the Development of Antibiological Agents/Sponsor: State of Nebraska - LB692

• Examination of Ornithine Decarboxylase Antizyme RNA Structure and Function from Various Organisms for the Development of Antibiological Agents/Sponsor: National Institutes of Health/NIH

• Autoclave Installation for INBRE Investigators/Sponsor: State of Nebraska - LB692

• BioTek LogPhase 600 Microbiology Reader/Sponsor: State of Nebraska - LB692

• Write Winning Grant Proposals Seminar/Sponsor: State of Nebraska - LB692

• Nebraska Research Network in Functional Genomics INBRE - CU Administration/Sponsor: University of Nebraska Medical Center/UNMC

• INBRE: Detection and Characterization of Compounds that Target the glmS Riboswitch and Act as Antibiotics/Sponsor: University of Nebraska Medical Center/UNMC

• INBRE Research Support/Sponsor: State of Nebraska - LB692

• INBRE Research Support/Sponsor: State of Nebraska - LB692

• INBRE: Detection and Characterization of Noncoding RNAs in Bacteria as Potential New Antibiotic Targets/Sponsor: University of Nebraska Medical Center/UNMC

• Administration and Planning Program/Sponsor: State of Nebraska - LB595

• Associate Vice Provost Biomedical Research Support/Sponsor: State of Nebraska - LB692

• Nebraska Research Network in Functional Genomics INBRE - CU Administration/Sponsor: University of Nebraska Medical Center/UNMC

Awards

• INBRE Scholars Program
  2016 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Samantha Stoupa
  National Institutes of Health
• INBRE Scholars Program
  2016 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Nicholas Bartschat - Exploration Of Cell Wall Permeability To Antibiotic glmS Riboswitch Analogs
  National Institutes of Health
• Summer Internship Program in Biomedical Research (SIP)
  2016 Summer Internship Program in Biomedical Research (SIP) at the National Institutes of Health awarded to Kathleen Marinelli
  National Institutes of Health
• Ferlic Summer Research Fellowship
  2016 Ferlic Summer Research Fellowship awarded by the Creighton University College of Arts & Sciences to Korey Krutsinger - Structural Studies of the Eukaryotic OAZ1 RNA
  CURAS
• Maiben lecture invited speaker
  Invited to give the Maiben lecture “Riboswitches turn students on to research" at the annual Nebraska Academy of Sciences meeting, Lincoln, NE, 2016
  Nebraska Academy of Sciences
• Invited Speaker
  Invited lecture “Catalytic Riboswitch Regulation of Gene Expression as a Target for Developing Novel Antibiotics”, Augsburg College Chemistry department, 2016.
• Council on Undergraduate Research Councilor
  Elected to a three-year term as a Council on Undergraduate Research (CUR) Councilor for the Undergraduate Research Program Directors (URPD) Division, 2016-2019
  Elected by Council on Undergradiate Research
• Invited Speaker
  Invited lecture “Persistence in science & strong female role models”, Clare Boothe Luce 25th Anniversary Professors conference, New York, NY, 2015.
• Chosen for SciMix Poster Presentation
  *Samantha Stoupa, *Daniel Poston, *Audrey Netzel, *Shelby Lennon, *Adam Kotula, *Heidi Klem, Garrett Soukup, and Juliane Soukup, “Identification of an Allosteric Twister Ribozyme for Use as a Synthetic Genetic Switch”, Midwest Regional American Chemical Society meeting, Saint Joseph, MO, 2015. PRESENTATION PROMOTED TO SPECIAL SCI MIXER POSTER SESSION ON THE FIRST NIGHT OF THE CONFERENCE
  American Chemical Society
• Ferlic Summer Research Fellowship
  2015 Ferlic Summer Research Fellowship awarded by the Creighton University College of Arts & Sciences to Daniel Kresock - Structural characterization of a spermine-binding mammalian riboswitch
  CURAS
• Summer Undergraduate Research Program
  2015 Mayo Clinic Summer Undergraduate Research Program awarded to Daniel Poston - Dasatinib Inhibits the Production of Inflammatory Mediators and Matrix Degrading Enzymes by Hdac-Suppressed Chondrocytes
  Mayo Clinic
• INBRE Scholars Program
  2015 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Nicholas Bartschat - A Deletion Analysis of TMEM261
  National Institutes of Health
• Invited Speaker
  “Phosphatase-Inert Glucosamine-6-Phosphate Mimics Serve as Actuators of the glmS Riboswitch”, Goethe University
• Invited Speaker
  "Phosphatase-Inert Glucosamine 6-Phosphate Mimics Serve as Actuators of the glmS Riboswitch", University of Konstanz
• Invited Speaker
  "Phosphatase-Inert Glucosamine 6-Phosphate Mimics Serve as Actuators of the glmS Riboswitch", University of Bonn, LIMES Institute
• Summer Research Fellowship
  2014 Honors Program Summer Research Fellowship awarded by the Creighton University Honors Program to Daniel Poston - Using the glmS riboswitch as a Synthetic Genetic Device
  Creighton Honors Program
• INBRE Scholars Program
  2014 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Katherine Bauer - Examination of the Structure and Function of a Mammalian Riboswitch in order to Design Anti-Cancer Drugs
  National Institutes of Health
• Ferlic Summer Research Fellowship
  2014 Ferlic Summer Research Fellowship awarded by the Creighton University College of Arts & Sciences to Daniel Kresock - Mechanistic Investigation of a Spermine-binding Mammalian Riboswitch
  CURAS
• Nominee for Undergraduate Research Fellows Award
  Council on Undergraduate Research Fellows Award
• INBRE Scholars Program
  2013 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Katherine Bauer – Investigation of conversion efficiency between natural and in vitro generated prions
  National Institutes of Health
• INBRE Scholars Program
  2013 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Alexander Stock - glmS Ribozyme Mechanism and Development and Delivery of Artificial Agonists as Candidate Antibiotics
  National Institutes of Health
• Best Oral Presentation
  *Zoran Pavlovic, *Shweta Goswami and Juliane K. Soukup. Evolutionary Conservation of a Potential Mammalian Riboswitch. 38th West Coast Biological Sciences Undergraduate Research Conference, San Diego, CA
  38th West Coast Biological Sciences Undergraduate Research Conference
• Best Undergraduate Poster
  *Alexander Stock and Juliane K. Soukup. glmS Ribozyme Mechanism and Development and Delivery of Artificial Agonists as Candidate Antibiotics. St. Albert's Day/Research Symposium, Creighton University
  St. Albert's Day Research Symposium
• Honorary Inductee
  Creighton University Alpha SIgma Nu (Jesuit Honor Society)
  Creighton University Alpha SIgma Nu (Jesuit Honor Society)
• College Award for Professional Excellence in Major Advising
  College Award for Professional Excellence in Major Advising, Creighton College of Arts & Sciences
  Creighton College of Arts & Sciences
• Award Winner
  Gordon Research Conference PUI (Predominantly Undergraduate Institution) Award
  Gordon Research Conference
• Ferlic Summer Research Fellowship
  2012 Ferlic Summer Research Fellowship awarded by the Creighton University College of Arts & Sciences to Brian Farrell - Examination of Spermine Riboswitch
  College of Arts & Sciences
• Ferlic Summer Research Fellowship
  2012 Ferlic Summer Research Fellowship awarded by the Creighton University College of Arts & Sciences to Lauren Hintz - Antibiotic properties of artificial agonists for bacterial riboswitch
  College of Arts & Sciences
• INBRE Scholars Program
  2012 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Zachariah Holmes - Structural Characterization of a Mammalian Riboswitch in the Spermine Biosynthetic Pathway
  National Institutes of Health
• INBRE Scholars Program
  2012 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Alexander Stock – A first glance at neurosensory miRNA knockout mice
  National Institutes of Health
• Outstanding Undergraduate Research in Biological Sciences
  UNMC Biomedical Research Training Program & the MD/PhD Scholars Program Award: *Zachariah Holmes, *Katie Del Vecchio, Jodi Monahan, *Chris Carlson, Juliane Soukup and Garrett Soukup. "Effect of microRNA-183 family on expression of genes that reinforce neurosensory cell fate in the inner ear." Nebraska Academy of Sciences annual meeting, Lincoln, NE
  Nebraska Academy of Sciences
• Creighton University Research Award
  Creighton University Research Award
• Richard Holland Future Scientist Award
  *Zachariah Holmes, Juliane Soukup and Garrett Soukup. Effect of microRNA-183 family on expression of genes that reinforce neurosensory cell fate in the inner ear. Tenth Annual Nebraska IDeA Networks of Biomedical Research Excellence Meeting, Grand Island, NE
  Nebraska IDeA Networks of Biomedical Research Excellence Meeting
• INBRE Scholars Program
  2011 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Zachariah Holmes – Effect of microRNA-183 family on expression of genes that reinforce neurosensory cell fate in the inner ear
  National Institutes of Health
• INBRE Scholars Program
  2011 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Katie Del Vecchio - A Putative Mammalian Riboswitch in the Spermine Biosynthetic Pathway
  National Institutes of Health
• INBRE Scholars Program
  2011 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Christina Nguyen - Structural Characterization and Analysis of Pre-Queuosine Riboswitch
  National Institutes of Health
• Ferlic Summer Research Fellowship
  2011 Ferlic Summer Research Fellowship awarded by the Creighton University College of Arts & Sciences to Shweta Goswami – Evolutionary Conservation of a Potential Mammalian Riboswitch
  College of Arts & Sciences
• INBRE Scholars Program
  2010 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Katie Del Vecchio - Validation of hair cell microRNA target genes involved in inner ear development and function
  National Institutes of Health
• INBRE Scholars Program
  2010 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Trang Ngoc Nguyen – Effect of prosensory cell-specific Dicer conditional knockout on mouse inner ear development
  National Institutes of Health
• Richard Holland Future Scientist Award
  2010 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Trang Ngoc Nguyen – Effect of prosensory cell-specific Dicer conditional knockout on mouse inner ear development - WON THIRD PLACE FOR HER ORAL PRESENTATION – RICHARD HOLLAND FUTURE SCIENTIST AWARD
• Ferlic Summer Research Fellowship
  2010 Ferlic Summer Research Fellowship awarded by the Creighton University College of Arts & Sciences to Donald Schrack – Structural Characterization and Analysis of Pre-Queuosine Riboswitch
  College of Arts & Sciences
• Ferlic Summer Research Fellowship
  2010 Ferlic Summer Research Fellowship awarded by the Creighton University College of Arts & Sciences to Erin Johnson - Antibiotic Development by Investigation of the glmS Riboswitch
  College of Arts & Sciences
• INBRE Scholars Program
  2010 National Institutes of Health INBRE (IDeA Networks for Biomedical Research Excellence) Summer Fellowship awarded to Andrew Kavan – Evolutionary Conservation of a Potential Animal/Mammalian Riboswitch
  National Institutes of Health
• Chosen for SciMix Poster Presentation
  *Kelley Wanzeck, *Natalie Erbs, *Katie Del Vecchio, and Juliane K. Soukup. Structure and Function of a Potential Mammalian Riboswitch. 239th American Chemical Society National Meeting, San Francisco, CA, 2010. PRESENTATION PROMOTED TO SPECIAL SCI MIXER POSTER SESSION ON THE FIRST NIGHT OF THE CONFERENCE
  American Chemical Society
• Nominee for Creighton University Research Award
  Creighton University Research Award
• Nominee for Carnegie Foundation U.S. Professors of the Year award
  Chosen as a representative from Creighton to be nominated for Carnegie Foundation U.S. Professors of the Year award